How To Delay The Progression Of Hiv To Aids
How does HIV turn into AIDS? Is it possible to delay the process? Yes. There is currently no cure for AIDS, but the condition can be delayed to give the person a longer period of good health. Each class of the medications works differently to control the virus. It is advisable to use a combination of three drugs from two classes.
- Non-nucleoside reverse transcriptase inhibitors . This class includes drugs like efavirenz, etravirine and nevirapine. These drugs work by disabling a protein required by the HIV virus to reproduce.
- Nucleoside or nucleotide reverse transcriptase inhibitors . This class of drugs includes abacavir. The drugs work by producing faulty protein that resemble those used by the HIV virus to reproduce.
- Protease inhibitors . This class includes atazanavir, darunavir, fosamprenavir and indinavir. These drugs inhibit protease, a protein required by the HIV virus to reproduce.
- Entry or fusion inhibitors. Entry inhibitors include enfuvirtide and maraviroc. These drugs delay the development of AIDS by inhibiting the entry of the HIV virus into the CD4 cells.
- Integrase inhibitors. Integrase inhibitors include raltegravir, elvitegravir and dolutegravir. Integrase is a protein used by the HIV virus to insert its DNA into the CD4 cells. These drugs function by inhibiting it.
When to Start Drugs
All people with HIV should be on antiretroviral drugs. However, drugs are particularly necessary in these situations:
Possible Side Effects
Whats The Difference Between Hiv And Aids
HIV is the virus that causes AIDS. AIDS stands for Acquired Immune Deficiency Syndrome. HIV and AIDS are not the same thing. And people with HIV do not always have AIDS.
HIV is the virus thats passed from person to person. Over time, HIV destroys an important kind of the cell in your immune system that helps protect you from infections. When you dont have enough of these CD4 cells, your body cant fight off infections the way it normally can.
AIDS is the disease caused by the damage that HIV does to your immune system. You have AIDS when you get dangerous infections or have a super low number of CD4 cells. AIDS is the most serious stage of HIV, and it leads to death over time.
Without treatment, it usually takes about 10 years for someone with HIV to develop AIDS. Treatment slows down the damage the virus causes and can help people stay healthy for several decades.
How Do Children Become Infected With Hiv
More than 90 percent of HIV infections in children result from mother-to-child-transmission, where the virus is passed from a mother living with HIV to her baby during pregnancy, childbirth, or breastfeeding. The risk of this form of transmission increases in direct relation to the severity of the mothers HIV infection.
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Progression From Hiv To Aids
In the final stage of HIV, a patients T-cell count falls as viral load increases the immune system becomes severely compromised. When the patient is diagnosed with a stage-4 HIV-related condition such as tuberculosis or cancer or pneumonia, the virus has made its progression to AIDS, Acquired Immunodeficiency Syndrome. Many of the symptoms and sickness at this point may be from opportunistic infections and not from AIDS itself. Once the virus has progressed to AIDS, the body is more likely to fail, though the time left to a patient ranges anywhere from just a few months to many years.
To learn more about what happens when HIV becomes AIDS, watch the video below, courtesy of YouTube:
The Test Does Not Work
The denialists say that neither the HIV antibody test, used to detect HIV infection, nor viral load and CD4+ cell counts, which measure disease progression, mean anything. These claims are sometimes accompanied by stories of the personal experience of the author of one of the AIDS denialist books, What if Everything You Thought You Knew about AIDS Was Wrong ? Christine Maggiore says she underwent a series of different HIV antibody tests and did not get consistent answers. Therefore, she concludes, the tests mean nothing.
Not all versions of the ELISA test are equally accurate, and this becomes particularly clear in other parts of the world. One of the reasons the U.S. government patented the original HIV antibody test in the mid-1980s was to enforce strong quality controls and to ensure the most consistent results. Rather than applauding this effort, writers like Maggiore betray their bias by suggesting the patent was sought out of greed by the researchers. The researchers themselves had nothing to do with seeking the patent, and at the time it was filed, government researchers could not profit from patents issued in their names.
More importantly, several large cohort studies have shown a profound and consistent relationship between a positive HIV antibody test result and the eventual development of AIDS. People who lack a positive result almost never experience opportunistic diseases, AIDS-like disease, or a similar decline in CD4+ cells .
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When Should You Call The Doctor If You Have Hiv Or You Think You Have Been Exposed To Hiv
There is also post-exposure prophylaxis , which is used in emergencies and should be started within 72 hours after the possible exposure. This involves taking antiretroviral therapy after this exposure. ART may be prescribed after sexual assault, or if you think you have been exposed during consensual sex or drug-taking.
If you already know you have HIV, you should follow your healthcare providers instructions on when to call. It is important to treat any type of infection, so call if you have new symptoms or things like a fever, sweating episodes, diarrhea, and so on. Its better to check with your doctor if you have any kind of symptom that worries you.
The main feature of managing AIDS is to continue to take your medicines and to fight back at opportunistic infections at the first sign of them.
Aids Diagnosis Is More Complicated
AIDS is late stage HIV infection. Healthcare providers look for a few factors to determine if HIV latency has progressed to stage 3 HIV.
Because HIV destroys immune cells called CD4 cells, one way healthcare providers diagnose AIDS is to do a count of those cells. A person without HIV can have anywhere from 500 to 1,200 CD4 cells. When the cells have dropped to 200, a person with HIV is considered to have stage 3 HIV.
Another factor signaling that stage 3 HIV has developed is the presence of opportunistic infections. Opportunistic infections are diseases caused by viruses, fungi, or bacteria that would not make a person with an undamaged immune system sick.
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How Does Chronic Hiv Affect The Body
The chronic HIV stage is known as the latent or asymptomatic stage. During this stage, a person usually wont have as many symptoms as they did during the acute phase. This is because the virus doesnt multiply as quickly.
However, a person can still transmit HIV if the virus is left untreated and they continue to have a detectable viral load. Without treatment, the chronic HIV stage can last for many years before advancing to AIDS.
Advances in antiretroviral treatments have significantly improved the outlook for people living with HIV. With proper treatment, many people who are HIV-positive are able to achieve viral suppression and live long, healthy lives. Learn more about HIV and life expectancy.
A normal CD4 count ranges from approximately 500 to 1,600 cells per cubic millimeter of blood in healthy adults, according to HIV.gov.
A person receives an AIDS diagnosis when they have a CD4 count of fewer than 200 cells/mm3.
A person may also receive an AIDS diagnosis if theyve had an opportunistic infection or another AIDS-defining condition.
People with AIDS are vulnerable to opportunistic infections and common infections that may include tuberculosis, toxoplasmosis, and pneumonia.
People with weakened immune systems are also more susceptible to certain types of cancer, such as lymphoma and cervical cancer.
The survival rate for people with AIDS varies depending on treatment and other factors.
Other Prevention Benefits Of Hiv Treatment
In addition to preventing sexual transmission of HIV there are other benefits of taking HIV medication to achieve and maintain an undetectable viral load:
- It reduces the risk of mother-to-child transmission from pregnancy, labor, and delivery. If a woman living with HIV can take HIV medication as prescribed throughout pregnancy, labor, and delivery and if HIV medication is given to her baby for 4-6 weeks after delivery, the risk of transmission from pregnancy, labor, and delivery can be reduced to 1% or less. Scientists dont know if a woman living with HIV who has her HIV under control can transmit HIV to her baby through breastfeeding. While it isnt known if or how much being undetectable or virally suppressed prevents some ways that HIV is transmitted, it is reasonable to assume that it provides some risk reduction.
- It may reduce HIV transmission risk for people who inject drugs. Scientists do not yet know whether having a suppressed or undetectable viral load prevents HIV transmission through sharing needles or other injection drug equipment, but it is reasonable to assume that it provides some risk reduction. Even if you are taking HIV medication and are undetectable, use new equipment each time you inject and do not share needles and syringes with other people.
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How Are Hiv And Aids Treated
Medicines can help people with HIV stay healthy. They can also prevent HIV from progressing to AIDS.
Health care providers prescribe a combination of different medicines for people with HIV and AIDS. They must be taken exactly as prescribed or they won’t work. These medicines:
- help keep the number of CD4 cells high
- reduce the viral load of HIV
Regular blood tests will check the number of CD4 cells in the body and the viral load.
If an HIV-positive person’s CD4 count gets low, doctors prescribe daily antibiotics. This prevents pneumocystis pneumonia, which happens in people with weakened immune systems.
Living With Hiv: What To Expect And Tips For Coping
More than 1.2 million people in the United States are living with HIV. Its different for everybody, but with treatment, many can expect to live a long, productive life.
The most important thing is to start antiretroviral treatment as soon as possible. By taking medications exactly as prescribed, people living with HIV can keep their viral load low and their immune system strong.
Its also important to follow up with a healthcare provider regularly.
Other ways people living with HIV can improve their health include:
- Make their health their top priority. Steps to help people living with HIV feel their best include:
- fueling their body with a well-balanced diet
- exercising regularly
- avoiding tobacco and other drugs
- reporting any new symptoms to their healthcare provider right away
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Who Is At Risk For Hiv Infection
Anyone can get HIV, but certain groups have a higher risk of getting it:
- People who have another sexually transmitted disease . Having an STD can increase your risk of getting or spreading HIV.
- People who inject drugs with shared needles
- Gay and bisexual men, especially those who are Black/African American or Hispanic/Latino American
- People who engage in risky sexual behaviors, such as not using condoms
Talk With Your Hiv Health Care Provider
Talk with your health care provider about the benefits of HIV treatment and which HIV medication is right for you. Discuss how frequently you should get your viral load tested to make sure it remains undetectable.
If your lab results show that the virus is detectable or if you are having trouble taking every dose of your medication, you can still protect your HIV-negative partner by using other methods of preventing sexual transmission of HIV such as condoms, safer sex practices, and/or pre-exposure prophylaxis for an HIV-negative partner until your viral load is undetectable again.
Taking HIV medicine to maintain an undetectable viral load does not protect you or your partner from getting other sexually transmitted diseases , so talk to your provider about ways to prevent other STDs.
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Hiv Can Be Transmitted From Person To Person
Because HIV is a virus, it can be transmitted between people just like many other viruses. AIDS, on the other hand, is a condition a person acquires only after theyve contracted HIV.
The virus is transmitted from one person to another through the exchange of bodily fluids. Most commonly, HIV is transmitted through sex without condoms or shared needles. Less so, a mother can transmit the virus to their child during pregnancy.
Taking Hiv Medication To Stay Healthy And Prevent Transmission
If you have HIV, it is important to start treatment with HIV medication as soon as possible after your diagnosis.
If taken every day, exactly as prescribed, HIV medication can reduce the amount of HIV in your blood to a very low level. This is called viral suppression. It is called viral suppression because HIV medication prevents the virus from growing in your body and keeps the virus very low or suppressed. Viral suppression helps keep you healthy and prevents illness.
If your viral load is so low that it doesnt show up in a standard lab test, this is called having an undetectable viral load. People living with HIV can get and keep an undetectable viral load by taking HIV medication every day, exactly as prescribed. Almost everyone who takes HIV medication daily as prescribed can achieve an undetectable viral load, usually within 6 months after starting treatment.
There are important health benefits to getting the viral load as low as possible. People living with HIV who know their status, take HIV medication daily as prescribed, and get and keep an undetectable viral load can live long, healthy lives.
There is also a major prevention benefit. People living with HIV who take HIV medication daily as prescribed and get and keep an undetectable viral load have effectively no risk of sexually transmitting HIV to their HIV-negative partners.
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Are Women More Likely To Get Hiv
Yes. Biologically speaking, a woman is more vulnerable to heterosexual transmission of the disease because the genitalia are easily exposed to seminal fluids.
Gender inequality has great influence on the spread of HIV/AIDS among women. In some cultures, many women and girls are often put in situations where they engage in non-consensual sex or have sex for money.
In the U.S., minority communities have been hit the hardest by HIV. African American and Hispanic women together represent less than 25% of all U.S. women, yet they account for more than 78% of AIDS cases reported among women in the country.
How Are These Disorders Diagnosed
Based on an individuals medical history and findings from a general physical exam, a physician will conduct a thorough neurological exam to assess various functions: motor and sensory skills, nerve function, hearing and speech, vision, coordination and balance, mental status, and changes in mood or behavior. The physician may order laboratory tests andone or more of the following procedures to help diagnose neurological complications of AIDS.
Brain imaging can reveal signs of brain inflammation, tumors and CNS lymphomas, nerve damage, bleeding, white matter irregularities, and other abnormalities. Several painless imaging procedures are used to help diagnose neurological complications of AIDS.
- Computed tomography uses x-rays and a computer to produce two-dimensional images of bone and tissue to show inflammation, certain brain tumors and cysts, brain damage from head injury, and other abnormalities. It provides more details than an x-ray alone.
- Magnetic resonance imaging uses a computer-generated radio waves, and a powerful magnetic field to produce either a detailed three-dimensional picture or a two-dimensional slice of body structures, including tissues, organs, bones, and nerves. It does not use the ionizing radiation that an x-ray does and provides a better look at tissue located near bone.
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How Can Hiv Infection In Children Be Prevented
The most effective method for preventing mother-to-child transmission of HIV is by initiating HIV-positive pregnant women on antiretroviral therapy as early as possible. ART decreases viral levels in the mothers bloodstream, thus reducing the risk that she will transmit the infection to her infant. ART should also be administered to a child before and after birth treatment will help a babys body resist infection.
Globally, an estimated 82% of pregnant or breastfeeding women living with HIV were receiving antiretroviral medicines to prevent transmission of HIV to their children in 2018.
What Research Is Being Done
Within the Federal government, the National Institute of Neurological Disorders and Stroke , a component of the National Institutes of Health , supports research on the neurological consequences of HIV and AIDS. NINDS works closely with its sister agencies, the National Institute of Allergy and Infectious Diseases and the National Institute of Mental Health , to fund research related to HIV and AIDS. The Office of AIDS Research coordinates AIDS research across NIH.
NINDS conducts research into how the weakened immune systems of individuals with AIDS lead to neurological illnesses. NINDS investigators are studying the JC virus, which can reproduce in the brains of people with impaired immune systems and cause progressive multifocal leukoencephalopathy . In one small NINDS study, the anti-cancer drug pembrolizumab showed promise in slowing or stopping the progression of PML. Additional research is needed to confirm results, which could lead to new investigations that help revolutionize treatment for similar chronic infections in immune compromised individuals.
Many individuals whose infection is successfully suppressed with cART experience a reactivation of the virus upon stopping treatment. Researchers are studying how a reservoir of inactive HIV is maintained in the brain. This research is a first step toward developing a means to render the virus permanently dormant or even to rid the brain of all traces of the virus.
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