Monday, March 4, 2024

How Does Truvada Work To Prevent Hiv

The Right Amount Of Time

My Experience Using PrEP/Truvada To Prevent HIV/AIDS

Infection of HIV in mucosal tissues occurs quickly. These data are reviewed in detail in . Knowing that an initial round of HIV replication can occur in mucosal tissue within 24 h of exposure suggests that antiretroviral drugs need to be at the site of infection before, or very shortly after, HIV exposure. Additionally, data demonstrating recoverable infectious virus up to 8 d after inoculation of cervical tissue cultures suggest that significant drug exposure may need to be available for days after exposure . Particular emphasis is being placed on longer-acting drug formulations for next-generation PrEP agents , which will require less frequent dosing and could be taken independently of virus exposure.

What Drugs Are Approved For Prep

The following medications approved for daily use as PrEP. They are combinations of two anti-HIV drugs in a single pill:

Can Prep Prevent Hiv Infection

San Francisco City Supervisor Scott Wieners decision to open up about taking Truvada brought the pre-exposure prophylaxis HIV prevention medication into the public eye. Just a few weeks later at a City Hall hearing, Wieners fellow supervisor David Campos requested an $807,000 budget to make Truvada more readily available.

What is PrEP, and how is Truvada changing the way we think about HIV prevention?

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Would Prep Be Right For You

PrEP could be helpful if the sex you are having is not always as safe as you would like it to be. If it is sometimes difficult to use condoms or to be sure of your partners HIV status, PrEP could make the sex safer. If its likely that some of your sexual partners have HIV without realising it, then PrEP could help protect your health.

People are not expected to take PrEP forever. PrEP is most likely to be useful for a period of months or years when the risk of HIV is greatest. If you no longer feel at risk, you can discuss stopping PrEP with your healthcare provider. Youll be able to re-start it later.

While PrEP provides extra protection against HIV, it does not protect against other sexually transmitted infections. Condoms can provide protection against gonorrhoea, chlamydia, syphilis and hepatitis C, as well as preventing unwanted pregnancy.

PrEP isnt the right choice for everyone. People who are able to consistently use condoms and other HIV prevention strategies dont need PrEP.

If your partners definitely dont have HIV, then PrEP isnt needed. And if you have a partner who is living with HIV, taking HIV treatment and has an undetectable viral load, there is no risk of HIV transmission anyway.

If it would be difficult for you to take pills regularly without missing doses, then PrEP would not be suitable. It might not be suitable for people who dislike the idea of relying on medication or dont want to go to regular medical appointments.

Truvada Whores Are A Thing

8 things you didnt know about Truvada

Because of the questions about whether PrEP will cause people to have risky sex and ditch condoms, there’s some related stigma in the gay community. People have even been slinging the term “Truvada whore” around, and the head of the AIDS Healthcare Foundation called Truvada a “party drug.” In response, one PrEP activist created a #TruvadaWhore t-shirt campaign to reclaim the word.

Many have pointed out that this divide parallels the early days of the birth control pill and suggestions that the medication would encourage promiscuity.

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Can You Mix Truvada With Other Substances

According to research , Truvada is known to interact with about 186 drugs. These interactions may range from severe to moderate and mild. Some of Truvada interactions include:

  • Kaletra
  • atazanavir
  • Norvir .

Thus, users of Truvada should be careful not to combine it with these medications to avoid adverse reactions . Apart from meds, Truvada could also interact with some health conditions such as the following:

  • hepatitis B
  • liver diseases
  • bone toxicity.

People who suffer from these conditions should consult their doctors for suitable alternatives. In the same vein, Truvada should not be used without proper medical consultation. Rather, one must undergo tests and consultations with a medical practitioner before using this medication.

I Prefer Sex Without A Condom So I Don’t Always Use Them Would Prep Still Work To Prevent Hiv If I Don’t Use Condoms

If a person takes the PrEP medication consistently as directed, it provides a high level of protection against HIV. Condoms provide protection against sexually transmitted infections . People who are on the PrEP medication but are not using condoms may be exposed to an STI. It is important to be aware that having an STI can increase a persons chance of getting HIV if exposed to the virus. Some STIs dont have symptoms or symptoms may disappear on their own for periods of time. If you are not using condoms regularly, it would be especially important to have regular testing for STIs and to get treated as soon as possible if you have an STI. Screening for chlamydia and gonorrhea should include swabs of a persons genitals, rectum and mouth. Learning about the signs and symptoms of STIs is helpful in identifying whether you or one of your partners has an STI. Condom use is recommended but choosing to not use condoms routinely should not prevent you from being prescribed PrEP.

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Where To Get Prep

PrEP is now available free on the NHS in England from sexual health clinics.

Initially, PrEP was made available to 10,000 people in England as part of the IMPACT trial, which ended in July 2020.

In Scotland, PrEP is available through sexual health clinics. Visit the PrEPScot website to find out more information about how to access it.

In Wales, PrEP is available through sexual health clinics. For more information, see the Public Health Wales website.

All GUM clinics in Northern Ireland will be offering initial consultation and assessment appointments for a pilot trial, based at a centralised service in Belfast. This project will run for 2 years. There is currently no cap on numbers.

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Taking PrEP has enabled me to trust again, have relationships and build bridges.

In clinical trials PrEP has been used in two different ways:

  • taken regularly .
  • only taken when needed .

This second method is often called on-demand or event based dosing.

Both methods have been shown to be very effective, although on-demand dosing has only been studied in gay and bisexual men.

Daily dosing is recommended for women who need to take PrEP every day for seven days to be protected against HIV.

Daily PrEP is recommended for all trans people using hormone treatment as there isnt sufficient data to support other dosing options.

What Are The Possible Side Effects Of Truvada

Does Truvada Prevent HIV/AIDS or Promote Unsafe Sex?

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with Truvada. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

Very common

  • Headache.
  • Abdominal pain, indigestion, bloating or wind .
  • Raised liver enyzmes.

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The Effectiveness Of Prep

Several studies have shown that PrEP significantly reduces the risk of HIV infection. The World Health Organization supports the use of PrEP .

PrEP can work for heterosexual men and women. In a study done with couples in Africa, it reduced infections by 75%. But some other studies had less impressive results, because too many of the people taking part did not take PrEP regularly.

post-exposure prophylaxis

A month-long course of antiretroviral medicines taken after exposure or possible exposure to HIV, to reduce the risk of acquiring HIV.

In studies, when PrEP appears not to have worked for someone, this was because the person was not actually taking the medication. In people who are able to take PrEP regularly, only occasionally missing doses, PrEP appears to prevent almost 100% of infections.

In a study done with gay men in England, use of Truvada as daily PrEP reduced HIV infections by 86%. In a study with gay men in France, PrEP taken before and after sex also reduced infections by 86%.

In a study, daily Truvada was found less effective for trans women. This was due to lower adherence and concern among trans people about interactions between daily Truvada and hormone therapy. However, interactions are unlikely due to differences in metabolism and clearance between PrEP and feminising hormones. Currently, there are no data on effectiveness of daily Truvada for trans men.

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  • Pre-exposure prophylaxis is an oral medication that prevents HIV in people at risk of infection with the virus.
  • PrEP reduces the risk of getting HIV by up to 99% when taken consistently as prescribed.
  • All GPs in Australia can prescribe PrEP.
  • PrEP doesnt protect against sexually transmissible infections . Condoms are still the best protection against infections .
  • HIV transmission can also be prevented by using condoms during anal or vaginal sex, using sterile injecting equipment, not sharing injecting equipment or achieving and maintaining undetectable HIV viral loads if you are HIV-positive.

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Can You Get Help Paying For Pep

  • If youre prescribed PEP after a sexual assaultYou may qualify for partial or total reimbursement for medicines and clinical care costs through the Office for Victims of Crime, funded by the U.S. Department of Justice .
  • If youre prescribed PEP for another reason and you cannot get insurance coverage Your health care provider can apply for free PEP medicines through the medication assistance programs run by the manufacturers. These requests can be handled urgently in many cases to avoid a delay in getting medicine.
  • If youre a health care worker who was exposed to HIV on the jobYour workplace health insurance or workers compensation will usually pay for PEP.

Drug Interactions With Truvada

Stop HIV. Start PrEP.

The following lists contain drugs that interact or have the potential to interact with the medications in Truvada . These lists are not exhaustive.

The manufacturer recommends that caution be used with the following drugs as there is the potential for serious drug interactions:

  • atazanavir + ritonavir
  • lopinavir/ritonavir
  • darunavir

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How Often Are Medical Appointments For Prep

People who want to take PrEP to prevent HIV can work with their healthcare provider to determine the schedule of medical appointments that best meets their needs. Here is a general description of the schedule of medical appointments for PrEP.

  • Initial Medical Appointment: This first appointment includes education about PrEP, a discussion about readiness to take PrEP, a review of daily versus on-demand PrEP, HIV testing, and other lab work. If the person is ready to start PrEP, the medication can be started right after the initial medical appointment.
  • First Follow-Up Contact: The healthcare provider and person should make a plan for a follow-up appointment or call at a convenient time, usually within 2-4 weeks, to:
    • Check in on how things are going, including side effects
    • Troubleshoot any problems with payment or access to support services.
  • HIV testing: The person should have an HIV testevery three months to make sure they have not acquired HIV. The healthcare provider can order the testing which can be done at their office, a conveniently located CBO, health facility or lab. It is important that the results of the test are provided to the healthcare provider who prescribed PrEP.
  • Follow-Up Appointments and Prescription Refills: The frequency of follow-up appointment is established jointly by the healthcare provider and the person.

Are There Any Side Effects Of Prep

As with most medications, some side effects come with taking PrEP though we deem these to be relatively low risk. The vast majority of people dont experience any problems whatsoever. However, some short-term effects may include:

  • an upset stomach
  • mild headaches, and
  • loss of appetite.

In rare cases, if taken over a long period of time, PrEP can decrease kidney function in those who have pre-existing medical conditions. To be safe, most GPs recommend PrEP users get regular kidney tests.

Taking a different perspective, there can also be positive side effects of PrEP namely improved mental health. For some people, the fear of acquiring HIV interferes their ability to relax and enjoy sex. PrEP can be an extra layer of protection in addition to condoms, so people know theyre as safe as possible.

An excellent article related to this topic is Sex Without Fear by journalist and novelist Tim Murphy.

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If I Drink Alcohol And/or Use Recreational Drugs Is It Safe To Take Prep

Alcohol and recreational drugs are not known to interact with PrEP medications. It is safe to take PrEP before, after and on days when you are “partying.” In fact, it is important to take extra steps to make sure you take PrEP according to the healthcare providers directions when you are “partying.”

What Are The Side Effects Of The Prep Medications

PrEP / Truvada for the Prevention of HIV / AIDS Infection

Truvada and Descovy are both recognized as well-tolerated medications with few side effects.

In clinical trials, only a small number of people found the side effects serious enough to stop taking the medication. People taking PrEP should discuss any side effects they experience with their healthcare provider. In many cases, side effects are only short term and can be managed. Two important health issues related to taking PrEP include kidney function and bone density. Your healthcare provider will ask if you have a history of kidney disease and will periodically order lab work to monitor your kidney function. Bone density will be monitored as needed. The NYSDOH is aware that there are lawsuits that claim harm to individuals taking Truvada. However, scientific evidence shows that when taken as directed, Truvada is safe and effective. Since there are risks to taking any medication, individuals should speak with their healthcare provider about the benefits, risks , and possible alternatives for every medication they choose to take in order to understand the best choices for their specific situation.

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Where Is Prep Available

Currently, PrEP is not available everywhere in the world and even in countries where it has regulatory approval it may not be easy to get hold of for a number of political or resourcing reasons.

In some countries PrEP is available for free, or subsidised as part of the national health system, in other countries you will have to pay for it privately.

The good news is that international guidelines now recommend that PrEP should be made widely available, so even if it’s not available to you right now, it may be an option in the future.

If you are interested in getting PrEP contact a healthcare professional who should be able to advise you on how you can do this. They will also be able to offer the advice, monitoring and support to help you take PrEP correctly and ensure you are fully protected.

There are also dedicated websites that can help you buy PrEP. However, taking PrEP without medical advice and monitoring has health risks, so you should always get a professional health check if you do buy PrEP online.

Who Should Consider Taking Prep

PrEP is for people who dont have HIV but who are at risk of getting HIV through sex or injection drug use.

Specifically, the Centers for Disease Control and Prevention recommends that PrEP be considered for people who are HIV negative who have had anal or vaginal sex in the past 6 months and:

  • have a sexual partner with HIV , or
  • have not consistently used a condom, or
  • have been diagnosed with a sexually transmitted disease in the past 6 months.

PrEP is also recommended for people without HIV who inject drugs and:

  • have an injection partner with HIV, or

PrEP should also be considered for people without HIV who have been prescribed non-occupational post-exposure prophylaxis and:

  • report continued risk behavior, or
  • have used multiple courses of PEP.

If you think PrEP may be right for you, talk to your health care provider.

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Can Truvada Cause Diabetes

Diabetes is not a side effect that has been reported in studies of Truvada. However, a kidney condition called nephrogenic diabetes insipidus has occurred in people taking Truvada. With this condition, the kidneys dont function correctly, and the person passes a large amount of urine. This can lead to dehydration.

If you have this condition and it becomes severe, your doctor may stop your treatment with Truvada.

Symptoms of nephrogenic diabetes insipidus can include:

  • dry skin

If you have questions about using Truvada to treat herpes, talk with your doctor or pharmacist.

Is It Ok To Switch Between Daily Prep And On

Truvada for HIV prevention backed by advisory panel, FDA ...

On-demand PrEP is only for cis-gender MSM. Other individuals are not eligible for on-demand PrEP because studies have not demonstrated that it is effective for other populations. Before switching from daily PrEP to on-demand PrEP, or vice versa, a cis-gender MSM should consult with their healthcare provider.

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