Multiclass Combination Drugs Or Single
The following combination drugs include both NRTIs and NNRTIs:
- doravirine, lamivudine, and tenofovir disoproxil fumarate
- efavirenz, lamivudine, and tenofovir disoproxil fumarate
- efavirenz, lamivudine, and tenofovir disoproxil fumarate
- · efavirenz, emtricitabine, and tenofovir disoproxil fumarate
- emtricitabine, rilpivirine, and tenofovir alafenamide fumarate
- emtricitabine, rilpivirine, and tenofovir disoproxil fumarate
Symfi and Symfi Lo are made up of the same generic medications. However, Symfi Lo contains a smaller dose of efavirenz.
The following combination drugs include NRTIs, an INSTI, and the CYP3A inhibitor cobicistat:
- elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate
- elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide fumarate
The following combination drugs include at least oneNRTI and an INSTI:
- abacavir, dolutegravir, and lamivudine
- bictegravir, emtricitabine, and tenofovir alafenamide fumarate
- dolutegravir and lamivudine
The manufacturer of Biktarvy also refers to it as being built on Descovy, or as bictegravir plus Descovy.
The following combination drug includes an NNRTI and an INSTI:
- dolutegravir and rilpivirine
The following combination drug includes NRTIs,a PI, and the CYP3A inhibitor cobicistat:
- darunavir, cobicistat, emtricitabine, and tenofovir alafenamide fumarate
Many HIV drugs can cause temporary side effects when first used. In general, these effects can include:
- diarrhea
- rash
- vomiting
How Does Acute Hiv Affect The Body
Once a person contracts HIV, the acute infection takes place immediately.
Symptoms of the acute infection may take place days to weeks after the virus has been contracted. During this time, the virus is multiplying rapidly in the body, unchecked.
This initial HIV stage can result in flu-like symptoms. Examples of these symptoms include:
- myalgias, or muscle pain
However, not all people with HIV experience initial flu-like symptoms.
The flu symptoms are due to the increase of copies of HIV and widespread infection in the body. During this time, the amount of CD4 cells starts to fall very quickly. The immune system then kicks in, causing CD4 levels to rise once again. However, the CD4 levels may not return to their pre-HIV height.
In addition to potentially causing symptoms, the acute stage is when people with HIV have the greatest chance of transmitting the virus to others. This is because HIV levels are very high at this time. The acute stage typically lasts between several weeks and months.
How Common Is Hiv
At the end of 2017, there were an estimated 5099 people in Scotland living with HIV. The majority got the virus through sex.
Around 1 in every 1087 people in the Scotland has HIV, but the three groups with highest rates of HIV are:
- gay and bisexual men or other men who have sex with men
- people from countries with high HIV prevalence, especially sub Saharan African countries
- people who share injecting equipment or who have sex with people who inject drugs
The World Health Organisation estimates that around 36.9 million people in the world are living with HIV.
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Lack Of Symptoms In Early Stages
ARS is common once a person has HIV. Still, this isnt the case for everyone. Some people have HIV for years before they know they have it. According to HIV.gov, symptoms of HIV may not appear for a decade or longer. This doesnt mean that cases of HIV without symptoms are less serious. Also, a person who doesnt experience symptoms could still transmit HIV to others.
Symptoms in early HIV tend to appear if the rate of cell destruction is high. Not having symptoms can mean that not as many CD4 cells, a type of white blood cell, are killed early on in the disease. Even though a person has no symptoms, they still have the virus. Thats why regular HIV testing is critical to prevent transmission. Its also important to understand the difference between a CD4 count and a viral load.
What Are The Complications Of Genital Herpes
Genital herpes may cause painful genital ulcers that can be severe and persistent in persons with suppressed immune systems, such as HIV-infected persons. 5 Both HSV-1 and HSV-2 can also cause rare but serious complications such as aseptic meningitis . 5 Development of extragenital lesions may occur during the course of infection. 5
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How Can You Identify A Maculopapular Rash
A maculopapular rash looks like red bumps on a flat, red patch of skin. The reddish background area may not show up if your skin is dark. The rash is sometimes itchy, and it can last from two days to three weeks depending on the cause.
How quickly the rash appears and where it appears on your body will differ depending on the cause of the rash. It can spread anywhere on the body, from the face down to the limbs. In some cases, your doctor may ask where the rash started on the body. This can help the doctor narrow down potential causes.
Since maculopapular rashes are most common in infections and body immune responses, more than one symptom may also appear. These include:
- fever
- our bodys own systemic inflammation
What Are Viral Load Blips
Even if a person is durably undetectable and taking antiretroviral therapy daily as prescribed, they may experience small, transient increases in viral load called blips followed by a decrease back to undetectable levels. Having a blip is relatively common and does not indicate that antiretroviral therapy has failed to control the virus. Scientists are working to better understand what causes blips.
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Can It Lie Dormant
The herpes virus can lie dormant in the body for years before people experience any symptoms.
After people have the first outbreak of herpes, the virus then lies dormant in the nervous system. Any further outbreaks are due to the virus reactivating, which causes symptoms to appear.
Symptoms are usually less severe during repeat outbreaks. Sores also clear up more quickly, often within 37 days. This is due to the antibodies the body produces to fight the first outbreak of herpes. The body can then use these antibodies to respond more quickly to future outbreaks.
There is currently no cure for herpes. Even if a person stops experiencing symptoms, the virus will remain inside their body.
It is also important to point out that herpes is transmissible even when no sores or other symptoms are present. For this reason, early prevention is advisable.
The herpes virus may be spread by direct skin-to-skin contact with the affected area. As a result, people can contract herpes from engaging in vaginal, anal, or oral sex with a person who has the herpes virus.
To help reduce the chance of this happening, people can use condoms or dental dams during sex.
Condoms and dental dams do not offer complete protection against the herpes virus, as herpes can live on areas around the genitals. However, these methods do reduce the likelihood of contracting the infection or passing it on.
Both people can then take additional steps to reduce the likelihood of transmission. These steps may include:
How Quickly Do Different Stis Spread
In Victorian times, sex was only acceptable within the confines of a marriage. Today, thankfully, things are different and people may be involved with several partners. But unfortunately, sexual freedom comes with a price tag in the form of exposure to sexually transmitted infections . There are many myths surrounding STIs and it’s important to know the facts – particularly when it comes to symptoms and how quickly they show up after exposure.
Reviewed byDr Sarah Jarvis MBE
07-Nov-17·4 mins read
Supported by sexual health charity FPA, a champion of peoples right to sexual and reproductive health and wellbeing.
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How Is Genital Herpes Diagnosed
HSV nucleic acid amplification tests are the most sensitive and highly specific tests available for diagnosing herpes. However, in some settings viral culture is the only test available. The sensitivity of viral culture can be low, especially among people who have recurrent or healing lesions. Because viral shedding is intermittent, it is possible for someone to have a genital herpes infection even though it was not detected by NAAT or culture. 11
Type-specific virologic tests can be used for diagnosing genital herpes when a person has recurrent symptoms or lesion without a confirmatory NAAT, culture result, or has a partner with genital herpes. Both virologic tests and type-specific serologic tests should be available in clinical settings serving patients with, or at risk for, sexually transmitted infections. 11
Given performance limitations with commercially available type-specific serologic tests , a confirmatory test with a second method should be performed before test interpretation. If confirmatory tests are unavailable, patients should be counseled about the limitations of available testing before serologic testing. Healthcare providers should also be aware that false-positive results occur. In instances of suspected recent acquisition, serologic testing within 12 weeks after acquisition may be associated with false negative test results. 11
Providers are strongly encouraged to look at CDCs STI Treatment Guidelines for further diagnostic considerations.
What Is Viral Suppression
Antiretroviral therapy keeps HIV from making copies of itself. When a person living with HIV begins an antiretroviral treatment regimen, their viral load drops. For almost everyone who starts taking their HIV medication daily as prescribed, viral load will drop to an undetectable level in six months or less. Continuing to take HIV medications as directed is imperative to stay undetectable.
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Treatment Of Acute Hiv Infection
Acute HIV infection is treated with antiretroviral drugs , which are drugs specially designed to treat retroviruses. People with HIV are prescribed a combination of antiretroviral drugs, which together are known as antiretroviral therapy .
Antiretroviral therapy reduces the amount of virus in the body. It does not cure HIV infection, but, taken correctly, it can slow progression of the condition from one stage to the next. For example, one recent study showed that a person diagnosed at age 20 who has appropriate treatment now has a life expectancy very close to that of a person without HIV.
Antiretroviral therapy should be started as soon as possible after diagnosis. It is very important to take antiretroviral medication correctly. Missing doses or stopping and restarting treatment can lead to drug resistance, which can reduce future treatment options.
Side-effects of ART may lead some people to consider stopping their medication. However, the long-term benefits of ART exceed the difficulties posed by some side-effects. It is very important not to stop taking ART without speaking with a doctor, who may be able to prescribe a more comfortable combination of antiretroviral drugs. More recent developments in ART mean that intolerable side-effects are fewer than in the past.
Side-effects associated with taking antiretroviral drugs include:
- Nausea
What Are Possible Complications
You may feel pain and itchiness due to the rash, but complications are unlikely to arise from the rash itself. What complications arise depend on the underlying cause. For example, you may develop life-threatening allergic reactions with certain drugs, which causes a skin reaction. Or you may develop headaches, a stiff neck, or back pain from an infection. As mentioned before, be sure to see a doctor who can look at all the symptoms youre having and make a diagnosis.
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What Is An Hiv Test
A confidential HIV test can be performed by your doctor. There are three types of tests that look at your bodily fluids to check for signs of HIV: nucleic acid tests , antigen/antibody tests, and antibody tests.
- NAT tests require drawing your blood to look for both the presence of HIV and how much of the virus is present, known as your viral load. The benefit of a NAT test is that it can detect HIV earlier than other types of tests. The downside is that these tests are very expensive. Typically, we use this test if youre exhibiting HIV infection symptoms or if youve had a high risk of exposure to the virus.
- Antigen/Antibody tests also draw blood, although there is a rapid test that requires a finger stick. This type of testing searches for antibodies that are produced in the blood by your immune system to fight the HIV invading cells. If HIV is in your body, you will produce an antigen called p24. The test looks for p24 as well as the antibodies that signal your body is fighting the infection.
- HIV Antibody tests just look for antibodies to HIV in your blood or oral fluids. These tests also require blood to be drawn from a vein.
The time for receiving test results spans several days to less than a few hours. Talk with your doctor about what type of test is right for you.
Days To 20 Years After Exposure
The chronic stage of infection occurs once the immune system brings the virus under control. During this phase, HIV will go into hiding, where it resides in various cells and tissues throughout the body in a dormant state known as latency. HIV latency can persist without symptoms for 10 years or more, although some people may experience signs within a year or two.
During the early chronic phase, lymphadenopathy may be the only notable sign of an HIV infection. In some cases, the glands may be visibly enlarged and reach up to an inch or more in size. If the condition persists for more than three months, its referred to as persistent generalized lymphadenopathy .
Even during latency, the virus will multiple imperceptibly and gradually deplete immune cells known as CD4 T-cells. As immune deficiency develops, a number of nonspecific symptoms are likely to appear, including:
- Oral candidiasis , a fungal infection that causes the formation of creamy, white lesions on the sides of the tongue and lining of the mouth
- Unexplained fevers and drenching night sweats that soak through bedsheets and nightclothes
- Severe, uncontrolled diarrhea that lasts for more than three days
Each of these symptoms is commonly seen in persons with immune deficiency. They may, in some cases, be caused by HIV itself or by an infection that has yet to be diagnosed.
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How To Tell If Symptoms Are Hiv
There are three types of HIV tests:
- An NAT involves drawing blood from a vein. It can tell if you have HIV or how much virus is present in your blood. While an NAT can detect HIV sooner than other types of tests, this test is very expensive and not routinely used for screening individuals unless they recently had a high-risk exposure, or a possible exposure and have early symptoms of HIV infection. This test takes several days for results to come back.
- An antigen/antibody test is recommended for testing done in labs and is now common in the United States. It involves drawing blood from a vein, and results take several days to come back. There is also a rapid antigen/antibody test available that is done with a finger prick and takes 30 minutes or less to get results.
- HIV antibody tests only look for antibodies to HIV in your blood or oral fluid. In general, antibody tests that use blood from a vein can detect HIV sooner after infection than tests done with blood from a finger prick or with oral fluid. Antibody tests can detect an HIV infection 23 to 90 days after exposure. Most rapid tests and the only currently approved HIV self-test are antibody tests. They take 20 minutes or less to provide results.
Keep in mind, any positive result would necessitate a second test to confirm it. The only test that would not require a second confirmatory test is the NAT.
What Are The Tests For Detecting Hiv
Various tests may be used for HIV detection:
- HIV antibody test: This test detects the antibodies produced in the body in response to HIV.
- Antigen test: This test can be done at an earlier stage than an HIV antibody test. It measures a protein called p24 antigen, present in the virus and produced in high amounts after the infection.
- Nucleic acid test : It is also called an RNA test. It is a very specific test that looks for the virus itself and can detect HIV as early as about 10 days of infections.
- In-home test kits: Although less accurate than the laboratory-based tests, home-based kits have the advantage of testing in the privacy and comfort of the home. Only FDA approved home-based kits should be used.
- Viral culture: This involves using the patients sample and growing the virus in the lab. It takes longer to get the results and is not the most preferred test for HIV.
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Other Symptoms To Watch For
Since an HIV rash signals a problem with the bodys immune system, many people will experience other symptoms along with a skin rash. These symptoms may include:
- Swollen lymph nodes
- Fever
- Flu-like symptoms, such as the chills, achy muscles, and a general feeling of illness
If your rash is especially large or causes swelling, you might also experience issues with mobility or getting around.
Hiv: A Brief Overview
HIV, or human immunodeficiency virus, is a sexually transmitted virus that spreads through exposure to certain body fluidsâlike genital secretions or blood. HIV transmission can also occur from a mother to a child during pregnancy, childbirth, or breastfeeding.
HIV attacks and impairs the bodyâs immune cells, which weakens the immune system and can eventually progress to acquired immunodeficiency syndrome if it isnât treated. AIDS can be a life-threatening condition, particularly if HIV treatment is not initiated promptly, which is why HIV testing is crucial for protecting your health.
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