Tuesday, October 4, 2022

Where Did The Hiv Virus Originate

Why Is Haiti Significant

Where did Aids come from?

In the 1960s, the ‘B’ subtype of HIV-1 had made its way to Haiti. At this time, many Haitian professionals who were working in the colonial Democratic Republic of Congo during the 1960s returned to Haiti.13 Initially, they were blamed for being responsible for the HIV epidemic, and suffered severe racism, stigma and discrimination as a result.

HIV-1 subtype M is now the most geographically spread subtype of HIV internationally. By 2014, this subtype had caused 75 million infections.14

Did Hiv Come From Monkeys

In 1999, researchers found a strain of SIV in a chimpanzee that was almost identical to HIV in humans.

The researchers who discovered this connection concluded that it proved chimpanzees were the source of HIV-1, and that the virus had at some point crossed species from chimps to humans.3

The same scientists then conducted more research into how SIV could have developed in the chimps. They discovered that the chimps had hunted and eaten two smaller species of monkeys . These smaller monkeys infected the chimps with two different strains of SIV.

The two different SIV strains then joined together to form a third virus that could be passed on to other chimps. This is the strain that can also infect humans.4

When And Where Did Hiv Start In Humans

Studies of some of the earliest known samples of HIV provide clues about when it first appeared in humans and how it evolved. The first verified case of HIV is from a blood sample taken in 1959 from a man living in what is now Kinshasa in the Democratic Republic of Congo. The sample was retrospectively analysed and HIV detected. There are numerous earlier cases where patterns of deaths from common opportunistic infections, now known to be AIDS-defining, suggest that HIV was the cause, but this is the earliest incident where a blood sample can verify infection.9

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Origin And Epidemiology Of Hiv/aids

UNAIDS reports that reaching Fast-Track Targets will avert nearly 28 million new HIV infections and end the AIDS epidemic as a global health threat by 2030.

If the world does not rapidly scale up in the next five years, the epidemic is likely to spring back with a higher rate of new HIV infections than today.

UNAIDS, 2014a

Your client, Mr. Glover, has been diagnosed with HIV. You dont know much about HIV and are concerned whether you can catch HIV by working with him or even shaking hands. You recognize your need to be better educated so you can give appropriate care without bias or fear. You know that quality care can be given when you have a sound understanding of the disease, risk factors, diagnostics, clinical symptoms, and treatments. Becoming culturally sensitive to the unique needs of your patients requires you to better understand your patients values, definitions of health and illness, and preferences for care.

Aids: Origin Of Pandemic ‘was 1920s Kinshasa’

Virus Hunt : The Search for the Origin of HIV/AIDs by ...

Health editor, BBC News website

The origin of the Aids pandemic has been traced to the 1920s in the city of Kinshasa, in what is now the Democratic Republic of Congo, scientists say.

An international team of scientists say a “perfect storm” of population growth, sex and railways allowed HIV to spread.

A feat of viral archaeology was used to find the pandemic’s origin, the team report in the journal Science.

They used archived samples of HIV’s genetic code to trace its source, with evidence pointing to 1920s Kinshasa.

Their report says a roaring sex trade, rapid population growth and unsterilised needles used in health clinics probably spread the virus.

Meanwhile Belgium-backed railways had one million people flowing through the city each year, taking the virus to neighbouring regions.

Experts said it was a fascinating insight into the start of the pandemic.

HIV came to global attention in the 1980s and has infected nearly 75 million people.

It has a much longer history in Africa, but where the pandemic started has remained the source of considerable debate.

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Unresolved Questions About Hiv Origins And Emergence

The discovery of the main HIV / SIV phylogenetic relationships permits explaining broad HIV biogeography: the early centres of the HIV-1 groups were in Central Africa, where the primate reservoirs of the related SIVcpz and SIVgor viruses exist similarly, the HIV-2 groups had their centres in West Africa, where sooty mangabeys, which harbour the related SIVsmm virus, exist. However, these relationships do not explain more detailed patterns of biogeography, such as why epidemic HIV-2 groups only evolved in the Ivory Coast, which is one of only six countries harbouring the sooty mangabey. It is also unclear why the SIVcpz endemic in the chimpanzee subspecies Pan troglodytes schweinfurthii did not spawn an epidemic HIV-1 strain to humans, while the Democratic Republic of Congo was the main centre of HIV-1 group M, a virus descended from SIVcpz strains of a subspecies that does not exist in this country. It is clear that the several HIV-1 and HIV-2 strains descend from SIVcpz, SIVgor, and SIVsmm viruses, and that bushmeat practice provides the most plausible cause of cross-species transfer to humans. However, some loose ends remain.

It is not yet explained why only four HIV groups spread considerably in human populations, despite bushmeat practices being widespread in Central and West Africa, and the resulting human SIV infections being common.

Did Hiv Start In Africa

Using the earliest known sample of HIV, scientists have been able to create a ‘family-tree’ ancestry of HIV transmission, allowing them to discover where HIV started.

Their studies concluded that the first transmission of SIV to HIV in humans took place around 1920 in Kinshasa in the Democratic Republic of Congo .10

The same area is known for having the most genetic diversity in HIV strains in the world, reflecting the number of different times SIV was passed to humans. Many of the first cases of AIDS were recorded there too.

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New Study Shows Hiv Epidemic Started Spreading In New York In 1970

A new genetic study confirms theories that the global epidemic of HIV and AIDS started in New York around 1970, and it also clears the name of a gay flight attendant long vilified as being “Patient Zero.”

Researchers got hold of frozen samples of blood taken from patients years before the human immunodeficiency virus that causes AIDS was ever recognized, and teased out genetic material from the virus from that blood.

They use it to show that HIV was circulating widely during the 1970s, and certainly before people began noticing a gay plague in New York in the early 1980s.

The Aids Epidemic Arises

Study Reveals Origins Of AIDS Pandemic: A ‘Perfect Storm’

Though HIV arrived in the United States around 1970, it didnt come to the publics attention until the early 1980s.

In 1981, the Centers for Disease Control and Prevention published a report about five previously healthy homosexual men becoming infected with Pneumocystis pneumonia, which is caused by the normally harmless fungus Pneumocystis jirovecii. This type of pneumonia, the CDC noted, almost never affects people with uncompromised immune systems.

The following year, The New York Times published an alarming article about the new immune system disorder, which, by that time, had affected 335 people, killing 136 of them. Because the disease appeared to affect mostly homosexual men, officials initially called it gay-related immune deficiency, or GRID.

Though the CDC discovered all major routes of the diseases transmissionas well as that female partners of AIDS-positive men could be infectedin 1983, the public considered AIDS a gay disease. It was even called the gay plague for many years after.

In September of 1982, the CDC used the term AIDS to describe the disease for the first time. By the end of the year, AIDS cases were also reported in a number of European countries.

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When Did Hiv Enter The Population

By looking at the genome sequences of different viruses over time, researchers can calibrate a molecular clock based on the rate of sequence change, or mutations. Scientists can then use this to infer the rate of evolution and thus determine approximately when the most recent common ancestor existed.

Using this technique, researchers estimated that HIV-1 group M originated in 1908 and group O in 1920. HIV-2 groups A and B originated a bit later approximately in 1940 and 1945, respectively.

Definitions Of Hiv And Aids

The human immunodeficiency virus has infected tens of millions of people around the globe in the past three decades, with devastating results. In its advanced stageacquired immunodeficiency syndrome the infected individual has no protection from diseases that may not even threaten people who have healthy immune systems. While medical treatment can delay the onset of AIDS, no cure is available for HIV or AIDS.

The human immunodeficiency virus kills or impairs the cells of the immune system and progressively destroys the bodys ability to protect itself. Over time, a person with a deficient immune system may become vulnerable to common and even simple infections by disease-causing organisms such as bacteria or viruses. These infections can become life-threatening.

The term AIDS comes from acquired immunodeficiency syndrome. AIDS refers to the most advanced stage of HIV infection. Medical treatment can delay the onset of AIDS, but HIV infection eventually results in a syndrome of symptoms, diseases, and infections. The diagnosis of AIDS requires evidence of HIV infection and the appearance of specific conditions or diseases beyond just the HIV infection. Only a licensed medical provider can make an AIDS diagnosis. A key concept is that all people diagnosed with AIDS have HIV, but an individual may be infected with HIV and not yet have AIDS.

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Case Definition For Epidemiological Surveillance

According to a study published in the Proceedings of the National Academy of Sciences in 2008, a team led by Robert Shafer at Stanford University School of Medicine has discovered that the gray mouse lemur has an endogenouslentivirus in its genetic makeup. This suggests that lentiviruses have existed for at least 14 million years, much longer than the currently known existence of HIV. In addition, the time frame falls in the period when Madagascar was still connected to what is now the African continent the said lemurs later developed immunity to the virus strain and survived an era when the lentivirus was widespread among other mammals. The study is being hailed as crucial, because it fills the blanks in the origin of the virus, as well as in its evolution, and may be important in the development of new antiviral drugs.

In 2010, researchers reported that SIV had infected monkeys in Bioko for at least 32,000 years. Previous to this time, it was thought that SIV infection in monkeys had happened over the past few hundred years. Scientists estimated that it would take a similar amount of time before humans adapted naturally to HIV infection in the way monkeys in Africa have adapted to SIV and not suffer any harm from the infection.

Sample Collection And Study Sites

Viremia: Definition, causes, and symptoms

Fecal samples were collected between July 2009 and June 2013 from wild western lowland gorillas in Cameroon and Gabon, eastern lowland gorillas in the DRC, and mountain gorillas in the DRC and Uganda. Most samples were collected around night nests and feeding sites, but also opportunistically . Samples were preserved in RNAlater , kept at ambient temperature in the field for a maximum of 3 wk and then stored at 20 °C or 80 °C. Field information included the global positioning system position and condition of fecal samples, as well as the number and age of gorilla nests.

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What Happened In The 1980s In The Usa

People sometimes say that HIV started in the 1980s in the United States of America , but in fact this was just when people first became aware of HIV and it was officially recognised as a new health condition.

In 1981, a few cases of rare diseases were being reported among gay men in New York and California, such as Kaposi’s Sarcoma and a lung infection called PCP.1516 No one knew why these cancers and opportunistic infections were spreading, but they concluded that there must be an infectious ‘disease’ causing them.

At first the disease was called all sorts of names relating to the word ‘gay’.17 It wasn’t until mid-1982 that scientists realised the ‘disease’ was also spreading among other populations such as haemophiliacs and heroin users.1819 By September that year, the ‘disease’ was finally named AIDS.20

It was only in 1983 that the HIV virus was isolated and identified by researchers at the Pasteur Institute in France. Originally called Lymphadenopathy-Associated Virus the virus was confirmed as the cause of AIDS, when scientists working at the USA National Cancer Institute isolated the same virus and called it HTLV-III. LAV and HTLV-III were later acknowledged to be the same.

Where We Are Now: 2000

Since 2000, additional factors have begun contribute to the the global spread of HIV. Heroin addiction in Asia has been on the rise, which brought with it dirty needles and the risk of new infections. India suffered with over 2 million diagnoses alone, in spite of the government’s refusal to admit the epidemic had adversely affected the nation.

The WHO released its comprehensive report examining HIV and AIDS in all of its 25-year history in 2010. This report had good news for developed nations: by 2008, the U.S. domestic HIV infection rate was considered effectively stable, and has remained so to this day. The report also demonstrated that while insistent public awareness campaigns about safe sex and other methods of transmission had slowed the rate of HIV infection in developed countries, there was much to be done elsewhere.

Global Education and Aid Efforts

Under President Bush, the U.S. committed funds to help African countries, but the funds were mismanaged and the spread of HIV continued unabated. Of the 4.1 million cases in sub-Saharan Africa then, only 1% received the available drugs. This led to the WHO’s declaration of the failure to treat the 6 million AIDS patients living in developing nations as a global public health emergency.

HIV Denialism Disrupts Aid

By the time Mbeki was recalled from the presidency in 2008 and one year before the FDA approved its 100th HIV/AIDs drug, an estimated 16.9% of South Africans aged 15-49 were HIV positive.

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What Is The ‘four

In 1983, the Centers for Disease Control in the United States listed the main at-risk groups, including partners of people with AIDS, people who inject drugs, haemophiliacs and people who have recently been to Haiti. At the time that cases of AIDS began to emerge in the USA, the absence of definitive information about HIV and its link to AIDS, inflated the panic and stigma surrounding the epidemic. Before long people began to talk colloquially of a 4-H Club at risk of AIDS: homosexuals, haemophiliacs, heroin addicts and Haitians, contributing to further stigmatisation.21

Are There Other Theories About How The Virus Could Have Gotten Into Humans

New documentary explores the truth behind the origin and rise of HIV/AIDS | Your Morning

There are several competing theories, ranging from implausible conspiracies to arguments grounded in extensive research. The best-known of the latter, the “OPV/AIDS” theory, was exhaustively detailed in the 1999 book The River, by author Edward Hooper. As many as a million Africans were given oral polio vaccines between 1957 and 1960. Hooper says witnesses have told him that a few batches of those vaccines were “grown” in chimp cells at a lab in Kisangani, a city in the Democratic Republic of the Congo — and that the chimp cells, and thus the vaccines, could have contained SIVs that jumped into humans. “There are highly significant correlations between the places where this vaccine was administered and the places where ⦠AIDS first appeared on the planet four to 20 years later,” Hooper says.

The majority of HIV researchers subscribe to the bushmeat theory and raise several arguments against the OPV theory. Hahn’s recent research confirming that HIV-1 M and N arose from Pan troglodytes troglodytes chimps in Cameroon presents one problem: The Kisangani lab is in the Democratic Republic of the Congo, and it’s home to a different subspecies of chimp than the one that was the source of HIV-1 M and N. However, it is possible that the chimps used in the Kisangani experiments were not from the area. In the spring of 2006, Hooper found a paper indicating that at least one of eight chimps at the Kisangani lab was a Pan troglodytes troglodytes.

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Homeless People And Intravenous Drug Users In New York

A volunteer social worker called Betty Williams, a Quaker who worked with the homeless in New York from the seventies and early eighties onwards, has talked about people at that time whose death would be labelled as “junkie flu” or “the dwindles”. In an interview for the Act Up Oral History Project in 2008, she said: “Of course, the horror stories came, mainly concerning women who were injection-drug users … who had PCP pneumonia , and were told that they just had bronchitis.” She continues: “I actually believe that AIDS kind of existed among this group of people first, because if you look back, there was something called junkie pneumonia, there was something called the dwindles that addicts got, and I think this was another early AIDS population way too helpless to ever do anything for themselves on their own behalf.”

Julia Epstein writes in her book Altered Conditions: Disease, Medicine and Storytelling that: “As we uncover more of the early history of HIV infection, it becomes clear that by at least the 1970s the virus was already making major inroads into the immune systems of a number of diverse populations in the United States and had for some time been causing devastation in several countries in Africa.”

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