Hiv Has A Powerful Opponent
Before 1996, contracting the HIV was basically a death sentence. But then, over the course of the next two decades, a regimen of drugs known as antiretroviral therapy evolved and came into use. This drug regimen helps prevent the virus from replicating and can help keep the infection from causing AIDS, transforming a fatal disease into a manageable one. These drugs have been an amazing scientific advancement, Dr. Santiago says. Most of the people who die nowadays are those who are unaware they have until symptoms become severe. Even people who think they may have been exposed to HIV have options if they act very quickly. The CDC advises you to alert your healthcare provider and start a regimen of ART medicines called post-exposure prophylaxis within 72 hours.
How Does Being Durably Undetectable Affect My Risk Of Transmitting Hiv To A Sexual Partner
People living with HIV who take antiretroviral medications daily as prescribed and who achieve and then maintain an undetectable viral load have effectively no risk of sexually transmitting the virus to an HIV-negative partner.
Three large multinational research studies involving couples in which one partner was living with HIV and the other was notHPTN 052, PARTNER and Opposites Attractobserved no HIV transmission to the HIV-negative partner while the partner with HIV had a durably undetectable viral load. These studies followed approximately 3,000 male-female and male-male couples over many years while they did not use condoms. Over the course of the PARTNER and Opposites Attract studies, couples reported engaging in more than 74,000 condomless episodes of vaginal or anal intercourse.
Things To Know About Hiv Suppression
A vial of blood
A vial of blood
Development of antiretroviral drugs to treat HIV has turned what was once an almost always fatal infection into a manageable chronic condition. Daily antiretroviral therapy can reduce the amount of HIV in the blood to levels that are undetectable with standard tests. Staying on treatment is crucial to keep the virus suppressed. NIAID-supported research has demonstrated that achieving and maintaining a durably undetectable viral load not only preserves the health of the person living with HIV, but also prevents sexual transmission of the virus to an HIV-negative partner.
Symptoms Of Hiv Infection
Most people experience a short flu-like illness 2 to 6 weeks after HIV infection, which lasts for a week or 2.
After these symptoms disappear, HIV may not cause any symptoms for many years, although the virus continues to damage your immune system.
This means many people with HIV do not know they’re infected.
Anyone who thinks they could have HIV should get tested.
Some people are advised to have regular tests as they’re at particularly high risk.
To 14 Days After Exposure
Known as acute retroviral syndrome, or ARS, the acute stage occurs immediately after being infected, when the immune system has yet to control the virus. During this time, an estimated 40 percent to 90 percent of people will experience mild to moderate flu-like symptoms, whereas the rest wont experience any symptoms at all.
Although these signs typically appear within 7 to 14 days of exposure, they can also crop up as early as 3 days. Around 30 percent of people with ARS will develop a maculopapular rash of pink to red bumps, usually on the upper half of the body. The rash will gradually converge into larger, raised hives.
Other common ARS symptoms include:
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Hiv Prevention Is Key
Because HIV is transmitted by the exchange of bodily fluids, the best way to prevent infection is to always practice safer sex and avoid using drug paraphernalia like needles. The CDC recommends that everyone between the ages of 13 and 64 get tested at least once for HIV, and as often as every six months if you have multiple sexual partners, have unprotected sex, or use needles to inject drugs. If youre at a very high risk for getting infected for example, if your current sexual partner has HIV taking a medication called pre-exposure prophylaxis, or PrEP, may help keep you safe, says the CDC. This preventive treatment lowers your chances of being infected by stopping the virus from getting a foothold in your body. The catch is that you have to take PrEP very consistently exactly as your doctor prescribes it. The CDC says this regimen can lower your risk of getting HIV from sex by 90 percent and cut the risk of transmission among injection drug users by more than 70 percent.
How Common Is Trichomoniasis
Trichomoniasis is the most common curable STD. In the United States, CDC estimates that there were more than two million trichomoniasis infections in 2018. However, only about 30% develop any symptoms of trichomoniasis. Infection is more common in women than in men. Older women are more likely than younger women to have been infected with trichomoniasis.
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What Are Viral Load Blips
Even if a person is durably undetectable and taking antiretroviral therapy daily as prescribed, they may experience small, transient increases in viral load called blips followed by a decrease back to undetectable levels. Having a blip is relatively common and does not indicate that antiretroviral therapy has failed to control the virus. Scientists are working to better understand what causes blips.
What Is Viral Suppression
Antiretroviral therapy keeps HIV from making copies of itself. When a person living with HIV begins an antiretroviral treatment regimen, their viral load drops. For almost everyone who starts taking their HIV medication daily as prescribed, viral load will drop to an undetectable level in six months or less. Continuing to take HIV medications as directed is imperative to stay undetectable.
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Stages Of Hiv Infection
The stages of infection from person to person vary slightly, both in severity and the speed of progression. These stages map the depletion of immune cells as the body’s defenses further and further degrade.
With each progression, the risk of opportunistic infections increases until the immune system is said to be fully compromised. It is at this stage that the risk of illness and death is particularly high.
The stages of infection can be roughly classified as follows:
How Long Does Hiv Survive Outside The Body
In general, the virus doesnât live long once itâs outside of a human body. Studies show that HIV grown in the lab, when placed on a surface, loses most of its ability to infect — 90% to 99% — within several hours. And the level of virus tested was much higher than whatâs found in bodily fluids. So contact with dried blood, semen, or other fluids poses little risk.
One study found HIV can live in used needles for over a month if the temperature and conditions are just right. That means sharing needles or syringes, like during drug use, raises your risk of infection.
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What Happens If I Stop Taking Antiretroviral Therapy
When therapy is stopped, viral load rebounds, and the risk of transmitting HIV to a sexual partner in the absence of other prevention methods returns. NIAID-supported research has provided clear-cut scientific evidence to support the benefits of staying on continuous antiretroviral treatment. In 2006, NIAIDs large clinical trial called SMART showed that people receiving intermittent antiretroviral treatment had twice the rate of disease progression compared to those receiving continuous treatment.
Taking antiretroviral treatment daily as directed to achieve and maintain durably undetectable status stops HIV infection from progressing, helping people living with HIV stay healthy and live longer, while offering the benefit of preventing sexual transmission. Stopping and re-starting treatment can cause drug resistance to develop, making that treatment regimen ineffective and limiting future treatment options.
Hiv Proteins Dysregulate Dopamine Signaling
To answer this, we used a mouse in which we can control the levels of HIV viral protein in order to probe the link between HIV infection and neurological disease.
Our lab discovered that an HIV protein, called HIV-1 Tat, reduces the level of an important protein required for the production of a dopamine, a neurotransmitter, in the brain.
Dopamine is produced by neurons in the central nervous system and by immune cells in the blood. Using a confocal microscope to see fine details, my colleagues and I carefully examined the dopamine producing areas in the brains of mice containing HIV-1 Tat protein and were surprised to discover that the neurons were alive. But, many that normally produced dopamine were unable to produce as much. We also found that an enzyme necessary to make dopamine, called tyrosine hydroxylase, was no longer detectable in some neurons. This suggests that the mice cant make as much dopamine.
When microglial cells secrete the HIV-1 Tat protein, it is able to enter dopamine neurons and lower their activity so that they produce less dopamine. That reduces their ability to communicate with other cells in the brain, which can disrupt the ability to move and reward related behaviors. Also, low levels of dopamine in an area of the brain called the substantia nigra is a hallmark of Parkinsons and predisposes patients to depression and addiction to drugs like methamphetamine and cocaine.
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Understanding Hiv And Aids
Generally speaking, the time it takes to go from HIV infection to AIDS is around five to 10 years if no medical intervention is made. Differences in time can be due to any number of factors, including:
- The genetic strain of HIV a person has been infected with
- The general health of the individual
- The place where the person lives
- A person’s genetics or family history
- Smoking and other personal lifestyle choices
This is, of course, if the person receives no treatment. The picture changes entirely if he or she does.
Since 1996, the introduction of antiretroviral drugs has dramatically altered the natural progression of HIV infection. While HIV still cannot be cured, people newly diagnosed with HIV who get treated and stay in care can be expected to have near-normal to normal life expectancies. As with other chronic diseases, early detection is key to identifying and treating the infection as soon as possible.
What Is The Treatment For Trichomoniasis
Trichomoniasis can be treated with medication prescribed by a doctor. These pills are taken by mouth. It is safe for pregnant women to take this medication.
People who have been treated for trichomoniasis can get it again. About 1 in 5 people get infected again within 3 months after receiving treatment. To avoid getting reinfected, all sex partners should get treated with antibiotics at the same time. Wait to have sex again until everyone has been treated and any symptoms go away . Get checked at 3 months to make sure you have not been infected again, or sooner if your symptoms come back before then.
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Stage : Acute Primary Infection
The early symptoms of HIV can feel like having the flu. Around one to four weeks after getting HIV, you may start to experience these flu-like symptoms. These normally dont last long . You may only get some of the symptoms and some people dont have any symptoms at all.
Symptoms can include:
- joint aches and pains
- muscle pain.
These symptoms happen because your body is reacting to the HIV virus. Cells that are infected with HIV are circulating throughout your blood system. In response, your immune system tries to attack the virus by producing HIV antibodies this process is called seroconversion. Timing varies but once you have HIV it can take your body up to a few months to go through the seroconversion process.
Having these symptoms alone does not mean you definitely have HIV. The only way to know if you have HIV is by taking a test. You should always visit your healthcare professional if youre worried about or think youve been at risk of getting HIV, even if you feel well and dont have any symptoms. They can then arrange for you to get tested.
HIV will not always show up in a test at this early stage, and you may need to test again later to confirm your result . Your healthcare professional will talk to you about the timing of your test and answer any concerns. Its important not delay speaking to a healthcare worker if you are worried about HIV.
Why Might People Living With Hiv Get Tested For Hiv
Because we connect with every single person who tests positive at one of our locations, we always ask why people get tested for HIV if theyve already been diagnosed in the past.
It happens for many reasons: People may test with a partner they havent yet disclosed to, they may have mental health concerns that come into play, or they need a letter of diagnosis to access services . Sometimes its because they are confused about the kind of information an HIV test will provide.
Now that weknow undetectable equals untransmittable , some people may have the misconception thatif youre undetectable, you will no longer test positive for HIV. They may think that if they test HIV-negative on an HIV test, theyll be able to show this to their sex partners as a way to prove that theyre undetectable and untransmittable. Or, they may think it will be easier to tell partners theyre HIV-negative rather than undetectable and uninfectious.
If you are living with HIV and have an undetectable viral load, you will still test positive for HIV. But, if you are living with HIV, have been taking HIV medications every day as directed, have a durably suppressed viral load and have been undetectable for at least six months, you will not transmit HIV to sex partners. You are not infectious. Thats the meaning of U=U.
Heres why you will still test positive for HIV even if you are undetectable.
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You Cant Get Hiv From Just Any Kind Of Contact
Myths still abound about HIV/AIDS. For example, you cant get HIV from insect bites or stings, hugging, shaking hands, or sharing toilets or dishes, according to the CDC. You also cant get infected from a closed-mouth kiss or contact with an infected persons sweat or tears. You cant get it by simply working or hanging out with someone who has AIDS or is HIV positive, either. HIV transmission from one woman to another woman through sexual contact is also rare, the CDC says.
A Timeline Of Hiv Symptoms
What is HIV?
HIV is a virus that compromises the immune system. Theres currently no cure for it, but there are treatments available to reduce its effects on peoples lives.
In the majority of cases, once HIV infection takes hold, the virus stays in the body for life. However, unlike what may occur with infections by other types of viruses, HIV symptoms dont suddenly appear and peak overnight.
If left untreated, the disease progresses over time through three stages, each with its own set of possible symptoms and complications some severe.
Regular antiretroviral treatment can reduce HIV to undetectable levels in the blood. At undetectable levels, the virus wont progress to the later stages of HIV infection. In addition, the virus cant be transmitted to a partner during sex.
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Lack Of Symptoms In Early Stages
ARS is common once a person has HIV. Still, this isnt the case for everyone. Some people have HIV for years before they know they have it. According to HIV.gov, symptoms of HIV may not appear for a decade or longer. This doesnt mean that cases of HIV without symptoms are less serious. Also, a person who doesnt experience symptoms could still transmit HIV to others.
Symptoms in early HIV tend to appear if the rate of cell destruction is high. Not having symptoms can mean that not as many CD4 cells, a type of white blood cell, are killed early on in the disease. Even though a person has no symptoms, they still have the virus. Thats why regular HIV testing is critical to prevent transmission. Its also important to understand the difference between a CD4 count and a viral load.
What Are The Signs And Symptoms Of Hiv
No two people with HIV will have the same symptoms, and some may not have any at all. But the infection can cause some common changes over time.
In the first few weeks: These first, flu-like symptoms happen because your body is reacting to HIV. Your immune system is trying to fight it off. The symptoms at this stage can include:
- Aches and pains in muscles and joints
Keep in mind that even if you have these symptoms, that doesnât automatically mean you are HIV-positive. Many different illnesses can cause these problems. Talk to a doctor or an HIV testing facility if you think you might be infected.
At this early stage of HIV infection, itâs important to know that you may not get accurate results from an HIV test. It can take 3-12 weeks for enough signs of the virus to show up on routine tests for the infection, which measure antibodies against HIV. A new kind of screening, called a nucleic acid test, can detect the virus itself during this early stage, but itâs expensive and not usually used for routine HIV testing.
Let the testing site or your doctor know if you think you might be recently infected. Also, be sure to use a condom every time you have sex, and take other steps to prevent spreading the virus.
After years with untreated HIV, youâre likely to get infections caused by bacteria, viruses, or fungi that your body is no longer strong enough to fight off. They can be a sign that your infection has gone from HIV to AIDS. You might have:
- Weight loss
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