The Biologic Basis For Aids
The specific details of the disease process that leads to AIDS are not fully understood despite considerable progress in the virology of HIV and the immunology of the human host, much of which has been driven by the urge to better understand AIDS.
There is a specific decline in the CD4+ helper T cells, resulting in inversion of the normal CD4/CD8 T-cell ratio and dysregulation of B-cell antibody production. Immune responses to certain antigens begin to decline, and the host fails to adequately respond to opportunistic infections and normally harmless commensal organisms. Because the defect preferentially affects cellular immunity, the infections tend to be nonbacterial .
The pattern of opportunistic infections in a geographic region reflects the pathogens that are common in that area. For example, persons with AIDS in the United States tend to present with commensal organisms such as Pneumocystis and Candida species, homosexual men are more likely to develop Kaposi sarcoma because of co-infection with HHV8, and tuberculosis is common in developing countries.
Gut-associated lymphoid tissue plays a role in HIV replication. Although the portal of entry for HIV infection is typically through direct blood inoculation or exposure of the virus to genital mucosal surfaces, the GI tract contains a large amount of lymphoid tissue, making this an ideal site for HIV replication.
How Long Does It Take For Hiv To Show Up Its Symptoms
Symptoms can vary depending on the stage of HIV you are in. Please look at the details below that may help you out if you suspect yourself as HIV positive.
- Acute HIV stage: Early symptoms occur two to four weeks after the first exposure at this phase. Please note that in some cases, there are no symptoms at this stage.
Although we managed to identify various symptoms associated with HIV, some cases dont show signs. Symptoms may not appear for a decade or longer. In this case, there could be a possibility of high HIV transmission to others.
What Does Hiv Do To A Person
HIV infects white blood cells of your immune system called CD4 cells, or helper T cells. It destroys CD4 cells, causing your white blood cell count to drop. This leaves you with an immune system that cant fight off infections, even those that wouldnt normally make you sick.
HIV initially makes you feel sick with flu-like symptoms. Then it can hide in your body for a long time without causing noticeable symptoms. During that time, it slowly destroys your T-cells. When your T-cells get very low or you begin to get certain illnesses that people with healthy immune systems dont get, HIV has progressed to AIDS.
AIDS can cause rapid weight loss, extreme tiredness, mouth or genital ulcers, fevers, night sweats and skin discolorations. Other illnesses and cancers often happen in people living with AIDS and can cause additional symptoms.
Whats a retrovirus?
A retrovirus is a virus that works backward from the way human cells do. Human cells have instructions that send a message to make building blocks for your body .
Retroviruses have their instructions written on RNA. When a retrovirus invades your cells, it changes its RNA to look like your cells instructions . Then it cuts your cells DNA and inserts its instructions into them. Your cell then acts as though the virus instructions are its own.
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How Is Hiv Treated
HIV is treated with a combination of medicines taken by mouth every day. This combination of pills is called antiretroviral therapy .
Taking a combination of types of pills, rather than just one, is the most effective way to keep HIV from multiplying and destroying your cells. There are also combination pills that have several medications in a single pill. Your healthcare provider will carefully select a combination specifically for you.
The goal of ART is to reduce HIV in the blood to an amount thats not detectable by an HIV test and to slow HIVs weakening of your immune system.
Medications used to treat HIV
Each type of pill used in ART has a different way of keeping HIV from making more copies of itself or from infecting your cells. There can be many different brand names of the same type of ART drug.
Types of ART medications include:
- Nucleoside reverse transcriptase inhibitors .
- Non-nucleoside reverse transcriptase inhibitors .
- Protease inhibitors .
- Combination of HIV medicines.
Days To 20 Years After Exposure
The chronic stage of infection occurs once the immune system brings the virus under control. During this phase, HIV will go into hiding, where it resides in various cells and tissues throughout the body in a dormant state known as latency. HIV latency can persist without symptoms for 10 years or more, although some people may experience signs within a year or two.
During the early chronic phase, lymphadenopathy may be the only notable sign of an HIV infection. In some cases, the glands may be visibly enlarged and reach up to an inch or more in size. If the condition persists for more than three months, its referred to as persistent generalized lymphadenopathy .
Even during latency, the virus will multiple imperceptibly and gradually deplete immune cells known as CD4 T-cells. As immune deficiency develops, a number of nonspecific symptoms are likely to appear, including:
- Oral candidiasis , a fungal infection that causes the formation of creamy, white lesions on the sides of the tongue and lining of the mouth
- Unexplained fevers and drenching night sweats that soak through bedsheets and nightclothes
- Severe, uncontrolled diarrhea that lasts for more than three days
Each of these symptoms is commonly seen in persons with immune deficiency. They may, in some cases, be caused by HIV itself or by an infection that has yet to be diagnosed.
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How Long Does It Take To See The Signs Of Hiv
The signs and symptoms of HIV may first appear within two to four weeks of infection. The stage in which the symptoms appear is called the stage of acute HIV infection. The symptoms appear due to the resistance or fight of the immune system against HIV. In the initial stage, the virus multiplies rapidly and spreads throughout the body. It targets and destroys the CD4 cells . As a result, the level of HIV in the blood and the chances of transmission at this stage are very high. It is crucial to recognize the early signs and seek medical help, since early diagnosis and treatment of HIV gets the best results.
Where Can I Go For Testing
Please contact your local health department HIV program.
FDOH-Escambia County offers free rapid HIV testing every first Thursday of the month from 4:30 p.m. 6:00 p.m. as well as Monday thru Friday from 8:30 a.m. 4:30 p.m. The number to call for FDOH-Escambia County is 595-6500, ext. 1503.
In addition, AHF provides free HIV testing Monday thru Friday from 8:00 a.m. 5:00 p.m. No appointment is necessary. OASIS provides free rapid HIV and Syphilis testing Monday thru Friday 9:00 a.m. 6:00 p.m. by appointments only.
One can also go towww.gettested.cdc.gov.
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Getting Your Test Results
If your blood is sent to the Public Health Lab it will take approximately 2-3 weeks for your test results to come back. You can call the clinic 2 weeks after your test to get the results.If Your Test is Negative
- It means you didnt have HIV antibodies in your blood at the time of your test
- If its been 3 months after your last exposure and your test is negative, you dont have HIV
- If its been less than 3 months you should be re-tested, ensuring safer-sex and needle sharing practices until the time of your next test.
If Your Test is Positive
- A positive test means you have antibodies for HIV.
- It does NOT automatically mean that you have AIDS.
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Is It Safe For Children With Hiv To Receive Routine Immunizations
MMR, or measles, mumps, and rubella vaccine, is safe to give to children with HIV, unless they have a severely weakened immune system.
DTaP/Td vaccine is safe to give to infants and children with HIV.
Hib and Hep B vaccines are safe to give to children with HIV.
Hepatitis A and B vaccines are safe to give to HIV-positive children.
VZIG should be considered for known HIV-positive children, depending on their immune status.
A yearly influenza vaccine is recommended for children with HIV, as well as any individual living in the same household as a child with HIV. There are two types of influenza vaccine children and adults with HIV should receive the “shot” form of the vaccine–not the nasal spray form, as it contains a live virus. Pneumococcal vaccine can be safely administered to age-appropriate HIV-infected children.
Always consult with your child’s doctor regarding immunizations for an HIV-infected child.
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What Is The Treatment For Hiv
Individuals who are HIV positive will likely need to see a specialist. As with many other conditions, early detection offers more options for treatment. Today, there are medical treatments that can slow down the rate at which HIV weakens the immune system. However, there are other treatments that can prevent or cure the conditions associated with HIV. Anti-retroviral drug therapy may be given to a pregnant woman, which has proven to greatly reduce the chance of an infant developing HIV. A cesarean section may be recommended to reduce infant transmission from the birth canal. In the U.S., where other feeding options are available, an infected mother should be discouraged from breastfeeding her infant. Consult your child’s doctor for more information regarding various drug therapies.
Letting Partners Know You Have Hiv
If you have just been diagnosed with HIV, it will likely be a difficult time. You might still be struggling to come to terms with diagnosis.
During this time, it is important to let any sexual or injecting partners know they may have been exposed to HIV as soon as you can, so they can be tested and offered PEP if appropriate.
You do not have to do this alone. Your doctor or the Department of Health and Human Services Partner Notification Officers can help you through this process and ensure your identity is not revealed.. Both groups can provide information, support, and guidance for people living with HIV.
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How Is Hiv Transmitted Or Spread
The following are the means by which the HIV virus is spread:
Vertical transmission. HIV can be spread to babies born to, or breastfed by, mothers infected with the virus.
Sexual contact. In adults and adolescents, HIV is spread most commonly by sexual contact with an infected partner. The virus enters the body through the lining of the vagina, vulva, penis, rectum, or abraded or irritated tissues in the lining of the mouth through sexual activity.
Blood contamination. HIV may also be spread through contact with infected blood. However, due to the screening of donated blood for evidence of HIV infection, the risk of acquiring HIV from blood transfusions is extremely low.
Needles. HIV is frequently spread by sharing needles, syringes, or drug use equipment with someone who is infected with the virus. Transmission from patient to health care worker, or vice-versa, through accidental sticks with contaminated needles or other medical instruments, is rare.
No known cases of HIV/AIDS have been spread by the following:
Enlarged lymph nodes
An HIV-infected child is usually diagnosed with AIDS when the immune system becomes severely damaged or other types of infections occur. As the immune system deteriorates, complications begin to develop. The following are some common complications, or symptoms, of the onset of AIDS. However, each child may experience symptoms differently. Symptoms may include:
Hiv Testing In A Health Care Setting Or Lab
If you take a test in a health care setting or a lab, a health care provider or lab technician will take a sample of your blood or oral fluid. If its a rapid test , you may be able to wait for the results, but if its a laboratory test, it can take several days for your results to be available. Your health care provider or counselor may talk with you about your risk factors, answer any questions you might have, and discuss next steps with you, especially if your rapid test result is positive.
- If the test comes back negative, and you havent had an exposure during the window period for the test you took, you can be confident you dont have HIV.
- If your HIV test result is positive, the lab will conduct follow-up testing, usually on the same sample as the first.
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What Is An Hiv Test
An HIV test shows whether you are infected with HIV . HIV is a virus that attacks and destroys cells in the immune system. These cells protect your body against disease-causing germs, such as bacteria and viruses. If you lose too many immune cells, your body will have trouble fighting off infections and other diseases.
There are three main types of HIV tests:
- Antibody Test. This test looks for HIV antibodies in your blood or saliva. Your immune system makes antibodies when you are exposed to bacteria or viruses, like HIV. An HIV antibody test can determine if you have HIV from 312 weeks after infection. Thats because it can take a few weeks or longer for your immune system to make antibodies to HIV. You may be able to do an HIV antibody test in the privacy of your home. Ask your health care provider about at-home HIV test kits.
- HIV Antibody/Antigen Test. This test looks for HIV antibodies and antigens in the blood. An antigen is a part of a virus that triggers an immune response. If youve been exposed to HIV, antigens will show up in your blood before HIV antibodies are made. This test can usually find HIV within 26 weeks of infection. The HIV antibody/antigen test is one of the most common types of HIV tests.
- HIV Viral Load. This test measures the amount of the HIV virus in the blood. It can find HIV faster than antibody and antibody/antigen tests, but it is very expensive. It is mostly used for monitoring HIV infections.
Can You Have Hiv For 20 Years And Not Know
While its common for people with HIV to experience symptoms similar to the flu after a few weeks of the initial infection, some people may experience no symptoms at all during the early stages of HIV.
If a person with HIV goes undiagnosed and the virus develops into stage 2, HIV will continue to develop and may last for 10-15 years without the appropriate HIV testing and treatment . Its important to note that this stage can also bring with it little to no symptoms and people may not even feel sick.
The only way to know your HIV status is to get tested. This can be done by visiting your local HIV testing centre, your local doctor, or from home with an at-home lab test. Early detection is crucial to getting prompt treatment and going on to lead both a happy and healthy life.
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Hiv Testing For Detection
Below are the HIV testing options that medical professionals do to determine if an individual is HIV positive.
Early signs recognition is a vital aspect so that patients can seek medical help immediately. In effect, HIV carriers can get more excellent results.
Which Test Can Give Me Results The Soonest
The period of time also differs, depending on which kind of test you take. The different types of tests include:
- Antibody tests, which look for the antibodies — special proteins that help fight infection — that your body makes in reaction to an HIV infection. Most rapid tests and at-home tests are these kind. Antibody tests require the longest wait time after infection to get an accurate result. For most people — around 97% — this takes anywhere from 2 to 12 weeks. For some, it can take as long as 6 months.
- Combination or fourth-generation tests, which look for both antibodies and antigens. Antigens are part of the virus itself. One antigen, p24, is detectable before your body starts making antibodies. These tests are becoming more common in the U.S. They can tell you if you have HIV a little sooner than an antibody test can.
- Nucleic acid tests , which can detect HIV in your body the soonest after infection. The test looks for the virus in your blood. You need a certain amount of the virus in your blood before the test will detect it. This is called your viral load. You can get a negative test if your viral load is still low. A NAT can tell you if you have HIV as early as 7 to 28 days after infection. It gives the quickest result, but itâs also the most expensive. Doctors donât typically use it unless youâre at a high risk of exposure to HIV.
Youâre more likely to have a NAT if you:
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