The Evolution Of Research And Treatment
In September 1985, President Ronald Reagan called AIDS research a top priority for his administration. This came amidst criticism that government funding was inadequate and not enough had been done to find a treatment or cure. This was Reagans first public statement about AIDS.
Zidovudine, commonly known as AZT, was introduced in 1987 as the first treatment for HIV. Scientists also developed treatments to reduce transmission during pregnancy.
In 1995, President Bill Clinton hosted the first White House Conference on HIV and AIDS, and called for a vaccine research center. This center later opened in 1999.
Throughout the years, the government has continued to fund HIV- and AIDS-related:
- systems of care
- studies and research
In 1996, in Vancouver, researchers at the 11th International Conference on AIDS introduced the concept of highly active antiretroviral therapy . This regimen requires people with HIV to take a combination of at least three medications daily. HAART, which is commonly known as antiretroviral therapy, became the new treatment standard in 1997.
Between 1996 and 1997, deaths from HIV in the United States, largely as a result of HAART.
Also in 1997, the FDA approved Combivir. Combivir combines the drugs zidovudine and lamivudine into a single medication, making HIV medications easier to take.
The FDA continues to approve HIV medical products, regulating:
- product approval
When And Where Did Hiv Start In Humans
Studies of some of the earliest known samples of HIV provide clues about when it first appeared in humans and how it evolved. The first verified case of HIV is from a blood sample taken in 1959 from a man living in what is now Kinshasa in the Democratic Republic of Congo. The sample was retrospectively analysed and HIV detected. There are numerous earlier cases where patterns of deaths from common opportunistic infections, now known to be AIDS-defining, suggest that HIV was the cause, but this is the earliest incident where a blood sample can verify infection.9
Vera Investigation Found That No Children Died From The Drugs
These allegations also spurred an investigation by the Vera Institute of Justice. In 2009, Vera published its findings, saying that there was no evidence to support the most grave allegations. Children did not die as a result of these drug trials, children were not forcibly separated from their families in order to participate in the trials, and this program did not target minority children. Vera found that some children suffered serious side effects from the drugs, but also noted that physicians adjusted their treatments to minimize these effects.
Here is an excerpt from this report:
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Origin And Distribution Of Sivgor
HIV-1 origins. The phylogenetic relationships of representative SIVcpz, HIV-1, and SIVgor strains are shown for a region of the viral pol gene . SIVcpz and SIVgor sequences are shown in black and green, respectively. The four groups of HIV-1, each of which represents an independent cross-species transmission, are shown in different colors. Black circles indicate the four branches where cross-species transmission-to-humans has occurred. White circles indicate two possible alternative branches on which chimpanzee-to-gorilla transmission occurred. Brackets at the right denote SIVcpz from P. t. troglodytes and P. t. schweinfurthii , respectively. The phylogenetic tree was estimated using maximum likelihood methods . The scale bar represents 0.05 nucleotide substitutions per site.
Stigma: Educating A Nation
The first year of the AIDS epidemic seemed isolated to a few individuals in a few cities, so it received little media attention. When cases were reported in infants and people with hemophilia, widespread panic struck Americans. Those with AIDS were often stigmatized. In 1985, Ryan White, a teenage hemophiliac living in Indiana, contracted AIDS from a blood transfusion. Parents in his community feared he would expose their children to AIDS, resulting in Ryan being barred from attending school.
In 1986, U.S. Surgeon General C. Everett Koop issued the Surgeon Generals Report on AIDS. In it, he called for a comprehensive program of sex and AIDS education, urged the widespread use of condoms, and dispelled myths that HIV could be spread by mosquitoes. In 1987, CDC launched an unprecedented national campaign, America Responds to AIDS . The goal of ARTA was to increase awareness and understanding of AIDS, to prevent HIV infection, and to encourage people to seek more information and counseling. CDC also began a program to support HIV prevention efforts with national minority organizations that provided HIV prevention expertise to community-based organizations, developed HIV prevention programs targeting minorities, especially African Americans and Hispanics, and supported groups that used culturally sensitive AIDS prevention programs to address their communities needs.
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Hiv/aids In The United States
|Rates of HIV Diagnoses in the US, 2017|
|New HIV Infections by Race and Transmission Group|
|HIV Diagnosis Trends in the U.S. and Dependent Areas, 20122016|
|The estimated number of U.S. HIV/AIDS Cases, in 2007 by transmission category|
The AIDS epidemic, caused by HIV , found its way to the United States as early as 1960, but was first noticed after doctors discovered clusters of Kaposi’s sarcoma and pneumocystis pneumonia in homosexual men in Los Angeles, New York City, and San Francisco in 1981. Treatment of HIV/AIDS is primarily via a “drug cocktail” of antiretroviral drugs, and education programs to help people avoid infection.
Initially, infected foreign nationals were turned back at the U.S. border to help prevent additional infections. The number of U.S. deaths from AIDS has declined sharply since the early years of the disease’s presentation domestically. In the United States in 2016, 1.1 million people aged over 13 lived with an HIV infection, of whom 14% were unaware of their infection.Gay and bisexual men, African Americans, and Latinos remain disproportionately affected by HIV/AIDS in the U.S.
Position Of The Plasma Fractionation Industry
On January 28, 1983, the American Resources Association , which represents the plasma industry, issued recommendations about donor screening and deferral to reduce the risk of . The recommendations focused on donor education, donor screening, and surrogate laboratory testing. The ABRA recommended issuing a brochure that would describe AIDS, tell how individuals in high-risk groups could reduce their risk of exposure, and discourage high-risk persons from donating. The ABRA also recommended that prospective donors, prior to donating, be required to read the information about AIDS and indicate that they were not members of a high-risk group. Individuals who identified themselves as members of high-risk groups or were unwilling to reply would be excluded from donating plasma . The ABRA recommended against large-scale surrogate testing of donated blood until ABRA had evaluated its feasibility.
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Origin And Distribution Of Sivcpz
Of the many primate lentiviruses that have been identified, SIVcpz has been of particular interest because of its close genetic relationship to HIV-1 . However, studies of this virus have proven to be challenging because of the endangered status of chimpanzees. The first isolates of SIVcpz were all derived from animals housed in primate centers or sanctuaries, although infection was rare in these populations. Collective analyses of nearly 2,000 wild-caught or captive-born apes identified fewer than a dozen SIVcpz positive individuals . Because other primate species, such as sooty mangabeys and African green monkeys, are much more commonly infected, both in captivity and in the wild , this finding raised doubts about whether chimpanzees represented a true SIV reservoir. To resolve this conundrum, our laboratory developed noninvasive diagnostic methods that detect SIVcpz specific antibodies and nucleic acids in chimpanzee fecal and urine samples with high sensitivity and specificity . These technical innovations, combined with genotyping methods for species and subspecies confirmation as well as individual identification, permitted a comprehensive analysis of wild-living chimpanzee populations throughout central Africa.
The Global Distribution Of Deaths From Hiv/aids
In some countries HIV/AIDS is the cause of more than a quarter of all deaths
Globally, 1.7% of deaths were caused by HIV/AIDS in 2017.
This share is high, but masks the wide variations in the toll of HIV/AIDS across the world. In some countries, this share was much higher.In the interactive map we see the share of deaths which resulted from HIV/AIDS across the world. Across most regions the share was low: across Europe, for example, it accounted for less than 0.1% of deaths.
But across some countries focused primarily in Southern Sub-Saharan Africa the share is very high. More than 1-in-4 of deaths in South Africa and Botswana were caused by HIV/AIDS in 2017. The share was also very high across Mozambique Namibia Zambia Kenya and Congo .
Death rates are high across Sub-Saharan Africa
The large health burden of HIV/AIDS across Sub-Saharan Africa is also reflected in death rates. Death rates measure the number of deaths from HIV/AIDS per 100,000 individuals in a country or region.
In the interactive map we see the distribution of death rates across the world. Most countries have a rate of less than 10 deaths per 100,000 often much lower, below 5 per 100,000. Across Europe the death rate is less than one per 100,000.
Across Sub-Saharan Africa the rates are much higher. Most countries in the South of the region had rates greater than 100 per 100,000. In South Africa and Mozambique, it was over 200 per 100,000.
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Tuberculosis Among People Living With Hiv
Tuberculosis is the leading HIV-associated opportunistic infection in low- and middle- income countries, and it is a leading cause of death globally among people living with HIV. Death due to tuberculosis still remains high among people living with HIV, however the number of deaths is decreasing. Most of the global mortality due to TB among those with HIV is from cases in Sub-Saharan Africa.
In the charts here we see the number of tuberculosis patients who tested positive for HIV the number receiving antiretroviral therapy and the number of TB-related deaths among those living with HIV.
People who use ART are living longer
ART not only saves lives but also gives a chance for people living with HIV/AIDS to live long lives. Without ART very few infected people survive beyond ten years.3
Today, a person living in a high-income country who started ART in their twenties can expect to live for another 46 years that is well into their 60s.4
ART prevents new HIV infections
There is considerable evidence to show that people who use ART are less likely to transmit HIV to another person.7 ART reduces the number of viral particles present in an HIV-positive individual and therefore, the likelihood of passing the virus to another person decreases.
We need to increase ART coverage
A New Pattern Emerges
On June 5, 1981, CDC published a report in the MMWR describing requests for the drug pentamidine to treat a deadly disease called Pneumocystis carinii pneumonia in five previously healthy young men in Los Angeles. After the reports publication, health officials also noticed a spike in cases of Kaposis sarcoma external icon among gay men in New York. Health officials were alarmed that outbreaks of both PCP and KS, which were rare, deadly diseases associated with immune suppression, appeared in the same part of the population.
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So Scientists Have Estimated When And Where The Most Deadly Type Of Hiv Started Infecting Humans
Most AIDS researchers believe that the “bushmeat trade” allowed the HIV-1 virus, and separately HIV-2, to enter the human bloodstream several times. Hunters who kill and butcher chimps and monkeys are regularly exposed to animal blood teeming with SIVs. If the hunters have cuts, bites, or scratches — and given the nature of their work they almost always do — they can catch the viruses from their prey. Hunters going after chimps in Cameroon could have caught the first strains of HIV-1. Sooty mangabeys, hunted and kept as pets in West Africa, could have transmitted HIV-2 to humans.
Africans have hunted chimps and monkeys and kept them as pets for centuries they’ve presumably been exposed to SIVs during most of that time. But the conditions needed for HIV to spread widely weren’t in place until after the continent was colonized and urbanized. The first victims would have found it easier to unwittingly spread the virus to sexual partners far and wide as roads and vehicles started connecting previously isolated villages and cities. Hospitals may have played a role, too. Strapped for cash, some of them probably re-used dirty needles, unknowingly infecting patients in the process.
The Cdc’s Public Meeting
The purpose of the public meeting on January 4, 1983, was to identify opportunities to prevent . The CDC’s objectives for the meeting were to tell the blood services community about the evidence they had gathered to enlist the help of other PHS agencies, especially the FDA and to formulate recommendations for the prevention of AIDS. According to data presented by the CDC, the manifestations of AIDS appeared 417 months after transmission of infection .
The meeting produced a great deal of debate but no consensus on specific action . Donald Francis, assistant director for medical science of the Division of Virology at the CDC, recommended that the blood banks question donors directly about their sexual behavior and run blood donations through a series of surrogate tests , including a test for the hepatitis B core antibody, which showed an 88 percent correlation with patients who had . Some meeting participants opposed this recommendation because of the cost of the tests and other reasons . Gay activist groups objected to screening measures, claiming that they were discriminatory toward their members. Many meeting participants were not convinced by the evidence that AIDS was transmitted by blood or blood products .
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Samples Collected From Wildlife In Thailand
While its true that most emerging diseases affecting humans come from wildlife, its often human behavior that is to blame for the spillover. Humans are tearing down forests and hunting, eating, and selling wild animals at unprecedented rates. Each exotic animal shipped across the ocean to be sold as a pet is an sveacasino opportunity for a new pathogen to take root in a new continent. Each tree ripped from its roots increases interactions between humans and wild animals, and thus the odds that viruses will find new populations to infect.
But the good news is: If were the ones causing the problem, were the ones who can stop it.
At EcoHealth Alliance, were striving toward a world where pandemics like the one caused by HIV/AIDS are a thing of the past. Join us.
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In fact, some researchers now think the very first HIV infection in humans may have happened more than 100 years ago, in 1908 or earlier. In his new book, Spillover , author David Quammen describes how viruses that attack wild animals can sometimes spill over. That means the viruses can start attacking people.
Scientists found clues to suggest this happened with HIV after detecting a very similar virus in monkeys and in chimpanzees and other great apes. Its called SIV, which stands for simian immunodeficiency virus. The types most similar to HIV appeared in chimpanzees living in the African country of Cameroon. Based on the most recent research, Quammen reports, SIV may have spilled over in that part of Africa and become the virus known as HIV. How? Researchers believe a chimp somehow passed the virus on to a person.
Some scientists suspect that a hunter killed an infected chimp for food . In the process, the hunter could have come into contact with the animals infected blood. Perhaps the hunter had a cut or open sore. After jumping to people, Quammen writes, the virus then likely simmered for decades in nearby villages and slowly spread from one villager to another. If people died from other causes or from a second infection that overwhelmed their damaged immune systems, no one would have known they had HIV.
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Federal Recommendations On The Prevention Of Aids
In a March 4, 1983 report, the PHS promulgated its first official recommendations on the prevention of . The recommendations stated that the evidence suggested the disease was a severe disorder of immune regulation caused by a transmissible agent . As evidence, the report indicated that the transmission routes of AIDS paralleled that of hepatitis B and that blood or blood products appeared to be responsible for transmitting AIDS to hemophilia patients. Suspected cases of transfusion-associated AIDS had been reported, but none were yet proven. According to the report, the evidence suggested a latency period of two months to two years between exposure and onset of symptoms. Brandt noted that a significant proportion of individuals in high-risk groups had no symptoms of AIDS, suggesting that the pool of persons potentially capable of transmitting an AIDS agent may be considerably larger than the known number of AIDS cases.
The PHS made the following recommendations for preventing transmission:
Where Did Aids Come From
Scientists have traced the origin of HIV back to chimpanzees and simian immunodeficiency virus , an HIV-like virus that attacks the immune system of monkeys and apes.
In 1999, researchers identified a strain of chimpanzee SIV called SIVcpz, which was nearly identical to HIV. Chimps, the scientist later discovered, hunt and eat two smaller species of monkeysred-capped mangabeys and greater spot-nosed monkeysthat carry and infect the chimps with two strains of SIV. These two strains likely combined to form SIVcpz, which can spread between chimpanzees and humans.
SIVcpz likely jumped to humans when hunters in Africa ate infected chimps, or the chimps infected blood got into the cuts or wounds of hunters. Researchers believe the first transmission of SIV to HIV in humans that then led to the global pandemic occurred in 1920 in Kinshasa, the capital and largest city in the Democratic Republic of Congo.
The virus spread may have spread from Kinshasa along infrastructure routes via migrants and the sex trade.
In the 1960s, HIV spread from Africa to Haiti and the Caribbean when Haitian professionals in the colonial Democratic Republic of Congo returned home. The virus then moved from the Caribbean to New York City around 1970 and then to San Francisco later in the decade.
International travel from the United States helped the virus spread across the rest of the globe.
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