Preventive Treatment Before Exposure
Taking an antiretroviral drug before being exposed to HIV can reduce the risk of HIV infection. Such preventive treatment is called preexposure prophylaxis . However, PrEP is expensive and is effective only if people take the drug every day. Thus, PrEP is recommended only for people who have a very high risk of becoming infected, such as people who have a partner who is infected with HIV.
PrEP may also be recommended for people who engage in high-risk sexual activities, such as the following:
Men who have anal sex with men without using a condom
Heterosexual men and women who do not regularly use condoms during sex with partners whose HIV status is unknown and who are at increased risk of HIV infection
People who use PrEP still need to use other methods to prevent HIV infection, including consistent use of condoms and not sharing needles to inject drugs.
You Do Not Get Aids From:
- Touching, social kissing, coughing, or sneezing
- Contact with eating utensils, water fountains, toilet seats, telephones, typewriters, etc.
- Teardrops, saliva, or sweat
- Using facilities such as public swimming pools, restrooms, or gymnasiums
- Being close to other people such as on a crowded bus, in a classroom, or restaurant
Hiv Effects On The Kidneys
High blood pressure and diabetes are both related to HIV, and both are major causes of kidney disease. The healthy diet and exercise habits that are good for your heart will help keep your blood pressure and blood sugar under control. That helps protect your kidneys, too.
Some HIV medications can damage your kidneys. If you already have kidney problems, your doctor may want to avoid those drugs or keep a close eye on their effects.
Your doctor will need to check your kidneys regularly because you might not notice the signs of kidney disease.
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What Are The Factors That Affect Disease Progression
The most important factor affecting HIV progression is the ability to achieve viral suppression. Taking antiretroviral therapy regularly helps many people slow the progression of HIV and reach viral suppression.
However, a variety of factors affect HIV progression, and some people progress through the phases of HIV more quickly than others.
Factors that affect HIV progression can include:
- Ability to achieve viral suppression. Whether someone can take their antiretroviral medications and achieve viral suppression is the most important factor by far.
- Age when symptoms start. Being older can result in faster progression of HIV.
- Health before treatment. If a person had other diseases, such as tuberculosis, hepatitis C, or other sexually transmitted diseases , it can affect their overall health.
- Timing of diagnosis. Another important factor is how soon a person was diagnosed after they contracted HIV. The longer between their diagnosis and treatment, the more time the disease has to progress unchecked.
- Lifestyle. Practicing an unhealthy lifestyle, such as having a poor diet and experiencing severe stress, can cause HIV to progress more quickly.
- Genetic history. Some people seem to progress more quickly through their disease given their genetic makeup.
Some factors can delay or slow the progression of HIV. These include:
Living a healthy lifestyle and seeing a healthcare provider regularly can make a big difference in a persons overall health.
How Does Acute Hiv Affect The Body
Once a person contracts HIV, the acute infection takes place immediately.
Symptoms of the acute infection may take place days to weeks after the virus has been contracted. During this time, the virus is multiplying rapidly in the body, unchecked.
This initial HIV stage can result in flu-like symptoms. Examples of these symptoms include:
- myalgias, or muscle pain
However, not all people with HIV experience initial flu-like symptoms.
The flu symptoms are due to the increase of copies of HIV and widespread infection in the body. During this time, the amount of CD4 cells starts to fall very quickly. The immune system then kicks in, causing CD4 levels to rise once again. However, the CD4 levels may not return to their pre-HIV height.
In addition to potentially causing symptoms, the acute stage is when people with HIV have the greatest chance of transmitting the virus to others. This is because HIV levels are very high at this time. The acute stage typically lasts between several weeks and months.
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Who Should Be Tested For Hiv
The CDC recommends that everyone age 13 to 64 get tested for HIV at least once.
People more vulnerable to HIV should get tested more frequently. The CDC defines people in this higher-risk group as those who have:
- Had more than one sex partner in the past year
- Had an HIV-positive partner
- Been diagnosed with or treated for hepatitis or tuberculosis or a sexually transmitted disease in the past year
- Exchanged sex for drugs or money
What Are The Symptoms Of Hiv And Aids
Within 2 to 4 weeks after infection with HIV, some people may have flu-like symptoms, such as fever, chills, or rash. The symptoms may last for a few days to several weeks. Other possible symptoms of HIV include night sweats, muscle aches, sore throat, fatigue, swollen lymph nodes, and mouth ulcers. Having these symptoms do not mean you have HIV. Other illnesses can cause the same symptoms. Some people may not feel sick during early HIV infection . During this earliest stage of HIV infection, the virus multiplies rapidly. After the initial stage of infection, HIV continues to multiply but at very low levels.
More severe symptoms of HIV infection, such as a badly damaged immune system and signs of opportunistic infections, generally do not appear for many years until HIV has advanced to AIDS. People with AIDS have badly damaged immune systems that make them prone to opportunistic infections.
Without treatment with HIV medicines, HIV infection usually advances to AIDS in 10 years or longer, though it may advance faster in some people.
HIV transmission is possible at any stage of HIV infectioneven if a person with HIV has no symptoms of HIV.
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How Can You Tell If A Woman Is Confident
- 9 Signs You Are Genuinely Confident, Without Seeming Cocky at All.
- You listen 10 times more than you speak.
- You take a stand not because you think you are always right, but because you are not afraid to be wrong.
- You duck the spotlight so it shines on others.
- You freely ask for help.
- You think, Why not me?
Respiratory And Cardiovascular Systems
HIV makes it hard to fight off respiratory problems such as the common cold and flu. In turn, an HIV-positive person may develop related infections, such as pneumonia.
Without treatment for HIV, advanced disease puts an HIV-positive person at an even greater risk for infectious complications, such as tuberculosis and a fungal infection called pneumocystis jiroveci pneumonia .
PJP causes trouble breathing, cough, and fever.
The risk of lung cancer also increases with HIV. This is due to weakened lungs from numerous respiratory issues related to a weakened immune system.
According to available research , lung cancer is more prevalent among people with HIV compared to people without it.
People with HIV are more likely to develop high blood pressure. HIV also raises the risk of pulmonary arterial hypertension . PAH is a type of high blood pressure in the arteries that supply blood to the lungs. Over time, PAH will strain the heart and can lead to heart failure.
If a person has HIV with a low CD4 count, theyre also more susceptible to tuberculosis .
TB is an airborne bacterium that affects the lungs. Its a leading cause of death in people who have AIDS. Symptoms include chest pain and a bad cough that may contain blood or phlegm. The cough can linger for months.
Can Hiv Be Prevented Or Avoided
The best way to prevent HIV is to not have sex with a person who has HIV, or share a needle with a person who has HIV. However, there is also a medicine called PrEP that people can take before coming into contact with HIV that can prevent them from getting an HIV infection.
PrEP stands for pre-exposure prophylaxis. It is for people who are at long-term risk of getting HIV either through sexual activity or by injecting drugs. If youre taking PrEP and come into contact with HIV, the medicine makes it difficult for HIV to develop inside your body.
Other ways to prevent HIV include:
- When you have sex, practice safer sex by using a condom. The best condom is a male latex condom. A female condom is not as effective but does offer some protection.
- Do not share needles and syringes.
- Never let someone elses blood, semen, urine, vaginal fluid, or feces get into your anus, vagina, or mouth.
How Hiv Is Spread
HIV is spread when blood, semen, or vaginal fluids from an infected person enter another person’s body, usually through:
- Sexual contact. The virus may enter the body through a tear in the lining of the rectum, vagina, urethra, or mouth. Most cases of HIV are spread this way.
- Infected blood. HIV can be spread when a person:
- Is accidentally stuck with a needle or other sharp item that is contaminated with HIV.
HIV may be spread more easily in the early stage of infection and again later, when symptoms of HIV-related illness develop.
A woman who is infected with HIV can spread the virus to her baby during pregnancy, delivery, or breastfeeding.
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Stage : Clinical Latency
If the infection goes undiagnosed or untreated, the immune system can bring the HIV level down some, but it cant completely control or contain it the virus is still active but multiplies more slowly, often without causing any symptoms. This is also called the clinical latency stage, or chronic HIV infection, and it can last up to 15 years.
How Hiv Suppresses The Immune System
To understand how HIV damages the immune system, we have to dive into some pretty scientific concepts.
The genetic makeup of an HIV viral cell has genetic material called RNA which helps it to reproduce more cells. For HIV cells to replicate, they need to latch onto healthy white blood cells called T cells. These cells contain certain proteins which HIV needs to duplicate itself and grow.
Your bodys immune system produces T cells to fight off infections but when an HIV cell takes hold, it will destroy the T cell to reproduce.
So, when a person is exposed to HIV, these cells will start to slowly reproduce in the body. The immune system will naturally pump out more T cells to try and fight off the virus but these cells will be destroyed by the HIV cells.
Eventually, this will leave the bodys immune system overwhelmed and totally defenseless to any disease. Once the bodys immune system is significantly weakened, then they may be diagnosed with AIDS, which stands for Acquired Immuno-Deficiency Syndrome. This progression of HIV to AIDS occurs over 5 to 10 years if the person does not receive any treatment.
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S For Removal And Inactivation Of The Infectious Agent
The production and purification of individual proteins from plasma is not sufficient to completely rem ove HIV. Therefore additional validated procedures for an effective depletion and inactivation of viruses must be applied . No transmissions of HIV by plasma derivatives have been reported since the consistent implementation of effective methods for removing and inactivating viruses in the production process. Accordingly, the experimentally determined inactivation capacity of the manufacturing process is supported by epidemiologic data.
HIV is sensitive to heat and detergents . HIV can be inactivated by the solvent-detergent technique, with reagents such as tri-n-butyl phosphate and Triton X-100 or polysorbate 80 . Pasteurisation at 60 °C for 10 h reliably inactivates HIV even in the presence of stabilisers . Heat treatment of lyophilized products inactivates HIV, provided there is appropriate residual moisture of about 1% .
Because of the heat sensitivity of plasma proteins the inactivation procedures must be carried out under appropriate validated conditions . The product should optimally maintain its biologic activity and native conformation, while potentially contaminating viruses should be inactivated under the production conditions . Treatment with -propiolactone and UV light is effective when applied at low protein concentrations, but not in plasma . The transmission of HIV by PCC preparations was not prevented by treatment with -propiolactone .
The Science Of Hiv And Aids
- HIV stands for Human Immunodeficiency Virus, a pathogen that works by attacking the human immune system.
- HIV specifically targets CD4 cells, the bodys principal defenders against infection, using them to make copies of themselves.
- Antiretroviral drugs target specific stages of the HIV lifecycle to stop HIV from replicating.
Explore this page to find out more about , , and .
HIV stands for Human Immunodeficiency Virus, a pathogen that works by attacking the human immune system. It belongs to a class of viruses called retroviruses and more specifically, a subgroup called lentiviruses, or viruses that cause disease slowly. 1
HIV cannot replicate on its own, so in order to make new copies of itself, it must infect cells of the human immune system, called CD4 cells. CD4 cells are white blood cells that play a central role in responding to infections in the body. 2
Over time, CD4 cells are killed by HIV and the bodys ability to recognise and fight some types of infection begins to decline. If HIV is not controlled by treatment, the loss of CD4 cells leads to the development of serious illnesses, or opportunistic infections. In people with normal CD4 cell levels, these infections would be recognised and cleared by the immune system. 3
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Can Stress And Anxiety Weaken Immune System
But if you repeatedly feel anxious and stressed or it lasts a long time, your body never gets the signal to return to normal functioning. This can weaken your immune system, leaving you more vulnerable to viral infections and frequent illnesses. Also, your regular vaccines may not work as well if you have anxiety.
How Is Hiv Spread
The spread of HIV from person to person is called HIV transmission. HIV is spread only through certain body fluids from a person who has HIV. These body fluids include:
- Rectal fluids
- Breast milk
HIV transmission is only possible through contact with HIV-infected body fluids. In the United States, HIV is spread mainly by:
- Having anal or vaginal sex with someone who has HIV without using a condom or taking medicines to prevent or treat HIV
- Sharing injection drug equipment , such as needles or syringes, with someone who has HIV
The spread of HIV from a woman with HIV to her child during pregnancy, childbirth, or breastfeeding is called perinatal transmission of HIV. For more information, read the HIVinfo fact sheet on Preventing Perinatal Transmission of HIV.
You cannot get HIV by shaking hands or hugging a person who has HIV. You also cannot get HIV from contact with objects, such as dishes, toilet seats, or doorknobs, used by a person with HIV. HIV is not spread through the air or water or by mosquitoes, ticks, or other blood-sucking insects. Use the HIVinfo You Can Safely ShareWith Someone With HIV infographic to spread this message.
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What Is Hiv Symptoms Causes Diagnosis Treatment And Prevention
Human immunodeficiency virus, or HIV, is a virus that attacks the bodys immune system specifically, white blood cells called CD4-positive T-helper cells.
When the immune system is weakened from AIDS, the body may have difficulty fighting off certain cancers or viral, fungal, or bacterial infections, and these conditions may prove fatal.
Transmission Of Hiv Infection
The transmission of HIV requires contact with a body fluid that contains the virus or cells infected with the virus. HIV can appear in nearly any body fluid, but transmission occurs mainly through blood, semen, vaginal fluids, and breast milk. Although tears, urine, and saliva may contain low concentrations of HIV, transmission through these fluids is extremely rare, if it occurs at all.
HIV is not transmitted by casual contact or by close, nonsexual contact at work, school, or home. No case of HIV transmission has been traced to the coughing or sneezing of an infected person or to a mosquito bite. Transmission from an infected doctor or dentist to a patient is extremely rare.
HIV is usually transmitted in the following ways:
HIV is more likely to be transmitted if skin or a mucous membrane is torn or damagedeven if minimally.
In the United States, Europe, and Australia, HIV has been transmitted mainly through men who have sex with men and the sharing of needles among people who inject drugs, but transmission through heterosexual contact accounts for about one fourth of cases. HIV transmission in Africa, the Caribbean, and Asia occurs primarily between heterosexuals, and HIV infection occurs equally among men and women. In the United States, fewer than 25% of adults who have HIV infection are women. Before 1992, most American women with HIV were infected by injecting drugs with contaminated needles, but now most are infected through heterosexual contact.
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Interval Of Mild Or No Symptoms
After the first symptoms disappear, most people, even without treatment, have no symptoms or only occasionally have a few mild symptoms. This interval of few or no symptoms may last from 2 to 15 years. The symptoms that most commonly occur during this interval include the following:
Swollen lymph nodes, felt as small, painless lumps in the neck, under the arms, or in the groin
White patches in the mouth due to candidiasis
Some people progressively lose weight and have a mild fever or diarrhea.
These symptoms may result from HIV infection or from opportunistic infections that develop because HIV has weakened the immune system.