How Long Are The Window Periods Of Different Hiv Tests
It is hard to say exactly how long the window period lasts, as there are variations between individuals and it is a difficult topic to research .
Nonetheless, a study by Dr Kevin Delaney and colleagues calculated window periods for a range of HIV testing assays. All these analyses were based on plasma samples. Window periods are likely to be several days longer when testing samples of fingerprick blood or of oral fluid, as will be normal when using rapid, point-of-care tests and self-testing devices. Unfortunately, precise figures for how much longer the window periods are have not yet been published.
The researchers analysis confirms that fourth-generation laboratory tests detect HIV infections between one and three weeks earlier than older antibody-only tests. Moreover, their data suggest that some countries guidelines which recommend retesting 90 days after a possible exposure to HIV are more cautious than they need to be.
Afourth-generation laboratory testis recommended in UK and US guidelines. It uses a sample of blood plasma or serum and can detect immunoglobulin G antibodies, immunoglobulin M antibodies and p24 viral antigen . Commonly used tests of this type include Abbott Architect HIV Ag/Ab, GS Combo Ag/Ab EIA and Siemens Combo HIV Ag-Ab.
- The median window period is 18 days . This indicates that half of all infections would be detected between 13 and 24 days after exposure.
- 99% of HIV-infected individuals would be detectable within 44 days of exposure.
Can Hiv/aids Be Prevented
You can reduce the risk of spreading HIV by:
- Getting tested for HIV
- Choosing less risky sexual behaviors. This includes limiting the number of sexual partners you have and using latex condoms every time you have sex. If your or your partner is allergic to latex, you can use polyurethane condoms.
- Getting tested and treated for sexually transmitted diseases
- Not injecting drugs
- Talking to your health care provider about medicines to prevent HIV:
- PrEP is for people who don’t already have HIV but are at very high risk of getting it. PrEP is daily medicine that can reduce this risk.
- PEP is for people who have possibly been exposed to HIV. It is only for emergency situations. PEP must be started within 72 hours after a possible exposure to HIV.
NIH: National Institutes of Health
Questions To Ask Your Doctor
- Is there any sure way to avoid acquiring HIV?
- What is the best treatment for me?
- How can I avoid getting any infections that will make me very sick?
- How can I find support groups in my community?
- What diagnostic tests will you run?
- How often will I need to see my doctor?
- Will there be any side effects to my treatment?
- How does this affect my plans for having a family?
- Is it safe for me to breastfeed my baby?
- Will using a condom keep my sex partners from acquiring HIV?
- Should I follow a special diet?
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How Does Chronic Hiv Affect The Body
The chronic HIV stage is known as the latent or asymptomatic stage. During this stage, a person usually wont have as many symptoms as they did during the acute phase. This is because the virus doesnt multiply as quickly.
However, a person can still transmit HIV if the virus is left untreated and they continue to have a detectable viral load. Without treatment, the chronic HIV stage can last for many years before advancing to AIDS.
Advances in antiretroviral treatments have significantly improved the outlook for people living with HIV. With proper treatment, many people who are HIV-positive are able to achieve viral suppression and live long, healthy lives. Learn more about HIV and life expectancy.
A normal CD4 count ranges from approximately 500 to 1,600 cells per cubic millimeter of blood in healthy adults, according to HIV.gov.
A person receives an AIDS diagnosis when they have a CD4 count of fewer than 200 cells/mm3.
A person may also receive an AIDS diagnosis if theyve had an opportunistic infection or another AIDS-defining condition.
People with AIDS are vulnerable to opportunistic infections and common infections that may include tuberculosis, toxoplasmosis, and pneumonia.
People with weakened immune systems are also more susceptible to certain types of cancer, such as lymphoma and cervical cancer.
The survival rate for people with AIDS varies depending on treatment and other factors.
What Std Can Cause Hair Loss
A sexually transmitted infection can cause hair loss if left untreated. STIs like syphilis are caused by genetic factors. It is possible to lose patchy hair on the scalp, eyebrows, beard, and other parts of the body when syphilis is left untreted. Hair loss can also occur when other STIs are present.
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What Behaviors Are The Most Risky For Getting Or Transmitting Hiv
Since there is a fairly high number of people who have HIV and dont know it, you should be tested for HIV so you know your status. Being intoxicated is risky because you are more likely to engage in risky sex if you are drunk or high. In terms of sex acts, anal sex and vaginal intercourse are the most risky behaviors.
What Are Some Of The Neurological Complications That Are Associated With Hiv Infection
AIDS-related disorders of the nervous system may be caused directly by the HIV virus, by certain cancers and opportunistic infections , or by toxic effects of the drugs used to treat symptoms. Other neuro-AIDS disorders of unknown origin may be influenced by but are not caused directly by the virus.
AIDS dementia complex , or HIV-associated dementia , occurs primarily in persons with more advanced HIV infection. Symptoms include encephalitis , behavioral changes, and a gradual decline in cognitive function, including trouble with concentration, memory, and attention. Persons with ADC also show progressive slowing of motor function and loss of dexterity and coordination. When left untreated, ADC can be fatal. It is rare when anti-retroviral therapy is used. Milder cognitive complaints are common and are termed HIV-associated neurocognitive disorder . Neuropsychologic testing can reveal subtle deficits even in the absence of symptoms.
Central nervous system lymphomas are cancerous tumors that either begin in the brain or result from a cancer that has spread from another site in the body. CNS lymphomas are almost always associated with the Epstein-Barr virus . Symptoms include headache, seizures, vision problems, dizziness, speech disturbance, paralysis, and mental deterioration. Individuals may develop one or more CNS lymphomas. Prognosis is poor due to advanced and increasing immunodeficiency, but is better with successful HIV therapy.
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Effects Of Antiretroviral Drugs On The Body
Antiretroviral therapy helps people who have HIV live longer, healthier lives and lowers their risk of spreading the virus. The drugs can have side effects, many of which go away with time. Overall, the benefits outweigh the risks.
There are several kinds of antiretroviral drugs, and your doctor might combine them in different ways. Side effects can vary from drug to drug or from person to person.
Common side effects of these drugs include:
- Upset stomach and vomiting
Protect Others From Becoming Hiv
Because you’re HIV-positive, you can give the virus to others, even if you don’t feel sick. This can happen through unprotected sex or by sharing needles. You can protect others by using condoms and clean needles. By doing this, you can also protect yourself from other strains of HIV. Also, don’t donate blood.
If you are a woman, you can spread HIV to your baby during pregnancy, birth, or breastfeeding. Ask your doctor what you can do to protect your child. Proper treatment has nearly wiped out the spread of infection to newborns in the U.S.
Uninfected sexual partners can take a daily pill called PrEP for extra protection against HIV.
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Stages Of The Hiv Lifecycle
Binding and fusion
HIV attaches to a T-helper cell. It then fuses to it and releases its genetic information into the cell.
The types of drugs that stop this stage of the lifecycle are called fusion or entry inhibitor drugs because they stop HIV from entering the cell.
Reverse transcription and integration
Once inside the T-helper cell, HIV converts its genetic material into HIV DNA, a process called reverse transcription. The new HIV DNA then enters the nucleus of the host cell and takes control of it.
The types of drugs that stop this stage of the lifecycle are called NRTIs , NNRTIs and integrase inhibitor drugs.
Transcription and translation
The infected T-helper cell then produces HIV proteins that are used to produce more HIV particles inside the cell.
Assembly, budding and maturation
The new HIV is put together and then released from the T-helper cell into the bloodstream to infect other cells and so the process begins again.
The type of drugs that stop this stage of the lifecycle are called protease inhibitor drugs.
What Are The Symptoms Of Hiv
Some people get flu-like symptoms a month or two after they have been infected. This is called the acute stage. These symptoms often go away within a week to a month.
You can have HIV for many years before feeling ill. This is called clinical latency or the chronic stage.
AIDS is the most severe stage of HIV infection. In this stage, the immune system has been weakened by the HIV virus and is less able to fight off infections. Opportunistic infections are infections that could generally be fought off by a healthy immune system. In order to be diagnosed with AIDS, you have to have fewer than 200 CD4 cells per cubic millimeter of blood , OR you must have developed what are called opportunistic infections or certain cancers. You can develop AIDS even if your CD4 count is not 200 or lower.
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How Are Hiv And Aids Treated
Medicines can help people with HIV stay healthy. They can also prevent HIV from progressing to AIDS.
Health care providers prescribe a combination of different medicines for people with HIV and AIDS. They must be taken exactly as prescribed or they won’t work. These medicines:
- help keep the number of CD4 cells high
- reduce the viral load of HIV
Regular blood tests will check the number of CD4 cells in the body and the viral load.
If an HIV-positive person’s CD4 count gets low, doctors prescribe daily antibiotics. This prevents pneumocystis pneumonia, which happens in people with weakened immune systems.
How Hiv Suppresses The Immune System
To understand how HIV damages the immune system, we have to dive into some pretty scientific concepts.
The genetic makeup of an HIV viral cell has genetic material called RNA which helps it to reproduce more cells. For HIV cells to replicate, they need to latch onto healthy white blood cells called T cells. These cells contain certain proteins which HIV needs to duplicate itself and grow.
Your bodys immune system produces T cells to fight off infections but when an HIV cell takes hold, it will destroy the T cell to reproduce.
So, when a person is exposed to HIV, these cells will start to slowly reproduce in the body. The immune system will naturally pump out more T cells to try and fight off the virus but these cells will be destroyed by the HIV cells.
Eventually, this will leave the bodys immune system overwhelmed and totally defenseless to any disease. Once the bodys immune system is significantly weakened, then they may be diagnosed with AIDS, which stands for Acquired Immuno-Deficiency Syndrome. This progression of HIV to AIDS occurs over 5 to 10 years if the person does not receive any treatment.
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Can Neurological Complications Develop In Individuals Treated With Antiretroviral Therapy
Even when HIV is well controlled with ART, many infected individuals still develop HIV-associated neurological and cognitive difficulties. This is because many drugs used to combat HIV cannot cross the protective layer called the blood-brain barrier and enter the brain, and even those that can may not completely control the virus in the brain. Antiretroviral drugs can also become toxic after long-term use and cause neurological side effects.
How Hiv Is Transmitted
HIV is not passed on easily from one person to another. The virus does not spread through the air like cold and flu viruses.
HIV lives in the blood and in some body fluids. To get HIV, 1 of these fluids from someone with HIV has to get into your blood.
The body fluids that contain enough HIV to infect someone are:
- semen
- vaginal fluids, including menstrual blood
- breast milk
- contact with animals or insects like mosquitoes
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How Is Hiv Diagnosed
Diagnosis of HIV infection during infancy depends on the detection of the virus. Since all infants born to HIV-infected mothers have a positive antibody test at birth because of the passive transfer of the HIV antibody across the placenta, virological testing is used to confirm the diagnosis.
For infants born to HIV-infected mothers, viral diagnostic testing is usually performed within the first 2 days of life, at 1 to 2 months of age, and at 4 to 6 months of age. A diagnosis of HIV infection can be made with two positive virologic tests obtained from different blood samples.
For children over 18 months, adolescents, or adults, diagnosis is made by testing the blood for the presence of HIV antibody.
How Is Hiv Treated
Treatments for HIV typically involve antiretroviral therapy. This isnt a specific regimen, but instead a combination of three or four drugs. The U.S. Food and Drug Administration has currently approved nearly 50 different medications to treat HIV.
Antiretroviral therapy works to prevent the virus from copying itself. This maintains immunity levels while slowing the progression of HIV.
Before prescribing medication, a healthcare provider will take the following factors into consideration:
- a persons health history
- the levels of the virus in the blood
HIV doesnt cause a lot of outward or noticeable symptoms until the disease has progressed. For this reason, its important to understand how HIV is transmitted and the ways to prevent transmission.
HIV can be transmitted by:
- having sex, including oral, vaginal, and anal sex
- sharing needles, including tattoo needles, needles used for body piercing, and needles used for injecting drugs
- coming into contact with body fluids, such as semen, vaginal fluid, blood, and breast milk
HIV is not transmitted by:
- breathing the same air as a person living with HIV
- getting bitten by a mosquito or other biting insect
- hugging, holding hands with, kissing, or touching a person living with HIV
- touching a door handle or toilet seat thats been used by an HIV-positive person
Keeping this in mind, some of the ways a person can prevent HIV include:
Symptoms can take years to appear, which is why its so important to get tested regularly.
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How Does Acute Hiv Affect The Body
Once a person contracts HIV, the acute infection takes place immediately.
Symptoms of the acute infection may take place days to weeks after the virus has been contracted. During this time, the virus is multiplying rapidly in the body, unchecked.
This initial HIV stage can result in flu-like symptoms. Examples of these symptoms include:
- myalgias, or muscle pain
However, not all people with HIV experience initial flu-like symptoms.
The flu symptoms are due to the increase of copies of HIV and widespread infection in the body. During this time, the amount of CD4 cells starts to fall very quickly. The immune system then kicks in, causing CD4 levels to rise once again. However, the CD4 levels may not return to their pre-HIV height.
In addition to potentially causing symptoms, the acute stage is when people with HIV have the greatest chance of transmitting the virus to others. This is because HIV levels are very high at this time. The acute stage typically lasts between several weeks and months.
When Should You Call The Doctor If You Have Hiv Or You Think You Have Been Exposed To Hiv
There is also post-exposure prophylaxis , which is used in emergencies and should be started within 72 hours after the possible exposure. This involves taking antiretroviral therapy after this exposure. ART may be prescribed after sexual assault, or if you think you have been exposed during consensual sex or drug-taking.
If you already know you have HIV, you should follow your healthcare providers instructions on when to call. It is important to treat any type of infection, so call if you have new symptoms or things like a fever, sweating episodes, diarrhea, and so on. Its better to check with your doctor if you have any kind of symptom that worries you.
The main feature of managing AIDS is to continue to take your medicines and to fight back at opportunistic infections at the first sign of them.
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Hiv Is An Infection That Can Lead To Aids
HIV stands for Human Immunodeficiency Virus. Its a virus that breaks down certain cells in your immune system . When HIV damages your immune system, its easier to get really sick and even die from infections that your body could normally fight off.
About 1.1 million people in the U.S. are living with HIV, and more than 38,000 new infections happen every year. Most people with HIV dont have any symptoms for many years and feel totally fine, so they might not even know they have it.
Once you have HIV, the virus stays in your body for life. Theres no cure for HIV, but medicines can help you stay healthy. HIV medicine lowers or even stops your chances of spreading the virus to other people. Studies show that using HIV treatment as directed can lower the amount of HIV in your blood so much that it might not even show up on a test when this happens, you cant transmit HIV through sex.Treatment is really important . Without treatment, HIV can lead to AIDS. But with medicine, people with HIV can live long, healthy lives and stop the spread of HIV to others.