Tuesday, September 27, 2022

What Does The Hiv Virus Do

How Do You Get Or Transmit Hiv

How is HIV Transmitted? Episode 2

You can only get HIV by coming into direct contact with certain body fluids from a person with HIV who has a detectable viral load. These fluids are:

  • Blood
  • Semen and pre-seminal fluid
  • Rectal fluids
  • Vaginal fluids
  • Breast milk

For transmission to occur, the HIV in these fluids must get into the bloodstream of an HIV-negative person through a mucous membrane open cuts or sores or by direct injection.

People with HIV who take HIV medicine daily as prescribed and get and keep an undetectable viral load have effectively no risk of sexually transmitting HIV to their HIV-negative partners.

Why Is Hiv So Evasive What Is The Hiv Reservoir

Although HIV can be controlled by antiretroviral therapy, it cannot be eliminated from the body. This is because HIV evades the normal immune system mechanisms for getting rid of cells infected by viruses.

HIV integrates itself into the DNA of human immune system cells and only replicates when the cell is stimulated to respond to an infection. These cells are called latently-infected cells. These cells are not recognised as infected by the immune system and killed off, allowing them to persist for as long as the cell lives.17

Some of the cells infected by HIV are very long-lasting memory T-cells. Reservoirs of latently- infected cells become established in the lymph nodes, the spleen and the gut. HIV also infects cells in the brain, but it is unclear if HIV can pass from the brain to other parts of the body. HIV may also persist for many years in macrophages immune cells found largely in tissues and in dendritic cells, which recognise infectious agents and alert other immune cells to remove them.

Latently-infected cells can proliferate without being activated and HIV may also pass from cell to cell within tissues in the gut and other reservoirs. 18 This means they evade the immune system and are not suppressed by antiretroviral drugs before infecting other cells.

How Are These Disorders Treated

No single treatment can cure the neurological complications of HIV/AIDS. Some disorders require aggressive therapy while others are treated as symptoms arise.

Neuropathic painchronic pain caused by damage to the nervous systemis often difficult to control. Medicines range from over-the-counter pain killers to anticonvulsant drugs, opiates, and some classes of antidepressants. Inflamed tissue caused by autoimmune or other conditions can press on nerves, causing pain. Such illnesses may be treated with corticosteroids or procedures such as plasma exchange, formally known as plasmapheresis, that clear the blood of harmful substances that cause inflammation.

Treatment options for AIDS- and HIV-related neuropsychiatric or psychotic disorders include antidepressants and anticonvulsants. Psychostimulants may also improve depression and reduce fatigue. Drugs such as cholinesterase inhibitors, which can temporarily improve or stabilize memory and thinking skills in people with dementia, may relieve confusion and slow mental decline. Benzodiazepines may be prescribed to treat anxiety. Psychotherapy may also help some individuals.

Other treatments may include physical therapy and rehabilitation, radiation therapy and/or chemotherapy to shrink cancerous brain tumors that may be related to HIV, antifungal or antimalarial drugs to combat certain bacterial infections associated with the disorder, and penicillin to treat neurosyphilis.

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How Do You Get Hiv

HIV is carried in semen , vaginal fluids, anal mucus, blood, and breast milk. The virus gets in your body through cuts or sores in your skin, and through mucous membranes . You can get HIV from:

  • having vaginal or anal sex

  • sharing needles or syringes for shooting drugs, piercings, tattoos, etc.

  • getting stuck with a needle that has HIV-infected blood on it

  • getting HIV-infected blood, semen , or vaginal fluids into open cuts or sores on your body

HIV is usually spread through having unprotected sex. Using condoms and/or dental dams every time you have sex and not sharing needles can help protect you and your partners from HIV. If you do have HIV, treatment can lower or even stop the chances of spreading the virus to other people during sex. If you dont have HIV, theres also a daily medicine called PrEP that can protect you from HIV.

HIV can also be passed to babies during pregnancy, birth, or breastfeeding. A pregnant woman with HIV can take medicine to greatly reduce the chance that her baby will get HIV.

HIV isnt spread through saliva , so you CANT get HIV from kissing, sharing food or drinks, or using the same fork or spoon. HIV is also not spread through hugging, holding hands, coughing, or sneezing. And you cant get HIV from a toilet seat.

Symptoms Of Hiv/aids And Stages

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Many people donât have symptoms at first, and sometimes even for years or decades. But there are signs that can happen, such as flu-like symptoms soon after you become infected with HIV. Even if you donât feel sick, HIV damages the immune system. It hijacks infection-fighting white blood cells called CD4 cells and uses them to churn out thousands of copies of itself. Without treatment, HIV destroys so many of these cells that your body canât protect you from life-threatening infections. If your CD4 count drops below 200, you have AIDS.

There are three stages of HIV infection:

Stage 1: This the earliest stage. You may also hear it called the âacuteâ stage. You might have a fever, rash, fatigue, chills, and other flu-like symptoms. But you might not have any symptoms. If you do, they may start 2-4 weeks after youâre infected. During this time, the virus quickly makes many copies of itself.

Stage 2: During this stage, HIV continues to reproduce, and it slowly damages your immune system over time. You might not feel sick or have symptoms. But HIV isnât gone, and you can still spread it to other people. This stage can last for years or even decades.

Stage 3: This is when you have AIDS. Your immune system has been severely damaged, leaving you vulnerable to other illnesses. With AIDS, many people have symptoms such as chills, fever, sweats, swollen lymph glands, weakness, and weight loss.

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What Are Hiv And Aids

HIV is the virus that causes AIDS . HIV attacks the immune system by destroying specific white blood cells called CD4 positive T cells that are vital to fighting off infection. The resulting shortage of these cells leaves people infected with HIV vulnerable to other infections and diseases, and additional complications.

AIDS is the final stage of HIV infection. A person infected with HIV is diagnosed with AIDS when he or she has a dangerously low number of CD4+ T cells as well as one or more opportunistic infections, such as some types of pneumonia or tuberculosis, that do not typically affect people with healthy immune systems.

Although HIV infection and AIDS primarily affect the immune system, they also disturb the nervous system and can lead to a wide range of severe neurological disorders, particularly if HIV goes untreated and progresses to AIDS. Many of the most severe neurological conditions can be prevented with antiretroviral therapy. However, even individuals who receive this treatment can develop less severe neurological and cognitive difficulties.

What Are The Symptoms Of Hiv/aids

The first signs of HIV infection may be flu-like symptoms:

  • Swollen lymph nodes
  • Mouth ulcers

These symptoms may come and go within two to four weeks. This stage is called acute HIV infection.

If the infection is not treated, it becomes chronic HIV infection. Often, there are no symptoms during this stage. If it is not treated, eventually the virus will weaken your body’s immune system. Then the infection will progress to AIDS. This is the late stage of HIV infection. With AIDS, your immune system is badly damaged. You can get more and more severe infections. These are known as opportunistic infections .

Some people may not feel sick during the earlier stages of HIV infection. So the only way to know for sure whether you have HIV is to get tested.

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Can Hiv Be Prevented

To reduce the risk of getting HIV, people who are sexually active should:

  • use a condom every time they have sex
  • get tested for HIV and make sure all partners do too
  • reduce their number of sexual partners
  • get tested and treated for STDs having an STD increases the risk of HIV infection
  • consider taking a medicine every day if they are at very high risk of getting infected

For everyone:

  • Do not inject drugs or share any kind of needle.
  • Do not share razors or other personal objects that may touch blood.
  • Do not touch anyone else’s blood from a cut or sore.

When Should You Call The Doctor If You Have Hiv Or You Think You Have Been Exposed To Hiv

How HIV infects us: Mucous membranes, dendritic cells, and lymph nodes | Khan Academy

There is also post-exposure prophylaxis , which is used in emergencies and should be started within 72 hours after the possible exposure. This involves taking antiretroviral therapy after this exposure. ART may be prescribed after sexual assault, or if you think you have been exposed during consensual sex or drug-taking.

If you already know you have HIV, you should follow your healthcare providers instructions on when to call. It is important to treat any type of infection, so call if you have new symptoms or things like a fever, sweating episodes, diarrhea, and so on. Its better to check with your doctor if you have any kind of symptom that worries you.

The main feature of managing AIDS is to continue to take your medicines and to fight back at opportunistic infections at the first sign of them.

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Screening And Diagnostic Tests

If doctors suspect exposure to HIV infection, they do a screening test for HIV. Doctors also recommend that all adults and adolescents, particularly pregnant women, have a screening test regardless of what their risk appears to be. Anyone who is concerned about being infected with HIV can request to be tested. Such testing is confidential and often free of charge.

The current combination screening test tests for two things that suggest HIV infection:

  • to HIV

  • HIV antigens

Antibodies are proteins produced by the immune system to help defend the body against a particular attack, such as that by HIV. Antigens are foreign substances that can trigger an immune response.

The body takes several weeks to produce enough antibodies to be detected by the test, so results of the antibody test are negative during the first few weeks after the virus enters the body . However, results of the p24 antigen test can be positive as early as 2 weeks after the initial infection. The combination tests can be done quickly by a laboratory. Also, a version of these tests can be done in a doctor’s office or clinic . If results are positive, doctors do a test to distinguish HIV-1 from HIV-2 and a test to detect the amount of HIV RNA in the blood .

Other, older rapid bedside tests are also available. These tests can be done using a sample of blood or saliva. If results of these rapid screening tests are positive, they are confirmed by ELISA or by repetition of one or more other rapid tests.

What Are The Signs & Symptoms Of Hiv And Aids

When first infected with HIV, a person may have:

  • fever
  • increased number of infections
  • infections that are more severe than is typical

Without treatment, HIV can lead to a very weakened immune system and progress to AIDS. Illnesses that happen in AIDS are called “AIDS-defining conditions.”

AIDS-defining conditions include:

  • very fast and severe weight loss
  • a lung infection called pneumocystis pneumonia
  • Kaposi sarcoma
  • lymphoma

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Mechanism Of Hiv Infection

Once in the body, HIV attaches to several types of white blood cells. The most important are certain helper T lymphocytes involves white blood cells that travel through the bloodstream and into tissues, searching for and attacking microorganisms and… read more ). Helper T lymphocytes activate and coordinate other cells of the immune system. On their surface, these lymphocytes have a receptor called CD4, which enables HIV to attach to them. Thus, these helper lymphocytes are designated as CD4+.

). Once inside a CD4+ lymphocyte, the virus uses an enzyme called reverse transcriptase to make a copy of its RNA, but the copy is made as deoxyribonucleic acid that contain the code for a specific protein that functions in one or more types of cells in the body. Chromosomes are structures within cells… read more ). HIV mutates easily at this point because reverse transcriptase is prone to making errors during the conversion of HIV RNA to DNA. These mutations make HIV more difficult to control because the many mutations increase the chance of producing HIV that can resist attacks by the persons immune system and/or antiretroviral drugs.

What Is A Retrovirus

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rather than as DNA DNA Genes are segments of deoxyribonucleic acid that contain the code for a specific protein that functions in one or more types of cells in the body. Chromosomes are structures within cells… read more .

When HIV enters a human cell, it releases its RNA, and an enzyme called reverse transcriptase makes a DNA copy of the HIV RNA. The resulting HIV DNA is integrated into the infected cells DNA. This process is the reverse of that used by human cells, which make an RNA copy of DNA. Thus, HIV is called a retrovirus, referring to the reversed process.

Other RNA viruses , unlike retroviruses, do not make DNA copies after they invade cells. They simply make RNA copies of their original RNA.

Each time an HIV-infected cell divides, it makes a new copy of the integrated HIV DNA as well as its own genes. The HIV DNA copy is either

  • Inactive : The virus is present but does no damage.

  • Activated: The virus takes over the functions of the infected cell, causing it to produce and release many new copies of HIV, which then invade other cells.

HIV-1 originated in Central Africa during the first half of the 20th century when a closely related chimpanzee virus first infected people. The global spread of HIV-1 began in the late 1970s, and AIDS was first recognized in 1981.

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Definition Of Exclusion Criteria

Blood donor eligibility is regulated by the Guidelines on the Collection of Blood and Blood Components and on Use of Blood Products . Criteria are defined for the permanent or temporary deferral from donation with respect to the transmission of HIV. Permanently deferred from donation are the following:

  • Persons with a confirmed HIV infection.

  • Persons with non-prescribed IV or IM drug use.

  • Persons whose sexual behaviour puts them at high risk of acquiring severe infectious diseases like HBV, HCV or HIV that can be transmitted by blood:

  • heterosexual persons with high-risk sexual behaviour, i.e. sexual contacts with multiple sex partners,

  • men who have sexual contacts with men

  • male and female sex workers.

Temporary deferral from donating blood is valid for persons:

  • who entered Germany from a country or a region, where they had been continuously resident for more than 6 months, with a comparatively high prevalence of HBV, HCV, HIV or HTLV-1/-2 infections,

  • who had sexual contacts with persons belonging to a group with an enhanced risk of infection with HBV, HCV, HIV and/or HTLV-1/-2 ,

  • with tattoos or body piercing.

Prevalence And Incidence Of Blood

Prior to the introduction of compulsory testing for HIV antibodies in May and October 1985, about 1,380 haemophiliacs and about 200 transfusion recipients were infected in Germany with HIV by blood donations and plasma derivatives . With the introduction of antibody screening tests and obligatory virus inactivation procedures in the production process of plasma derivatives, the number of HIV and hepatitis virus infections by transfusion declined significantly, especially in the first 2 years. Since 2004, HIV antibody testing and HIV NAT further reduced the potential HIV burden of the source material . Since 1990/1991 no HIV infections have been transmitted by plasma derivatives .

According to reports to the Paul Ehrlich Institute, 2 HIV transmissions by cellular blood components have occurred after the introduction of NAT screening in 2004 . Both transmissions were due to very recent infections and a failure of the NAT systems used. In the case of 2007, presumably a low viral load and mutations in the primer binding region were responsible for the false-negative test results . Regarding the transmission reported in 2009, the HIV-positive donor sample was repeatedly tested negative with the NAT system used .

As recommended for HIV-infected donors, plasma and lymphocytes of the HIV-infected recipient should also be stored in order to possibly clarify the origin of infection and the transmission using molecular methods .

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How Do People Get Hiv

Most young children who have HIV got it before they were born or shortly after birth.

Older people can get HIV through:

  • sex
  • sharing needles for injecting drugs or tattooing
  • getting stuck with a needle with an infected persons blood on it

HIV is NOT spread through:

  • pee, poop, spit, throw-up, or sweat
  • coughing or sneezing
  • sharing eating utensils or drinking glasses

Hiv Effects On The Skin

What is HIV? | How is HIV Transmitted?

Many people get a skin rash in the first stage of an HIV infection. It usually goes away without treatment in days or weeks. Over time, a number of things might cause more rashes. Itâs always important to let your doctor know about a rash, because it might be a sign of a serious problem, or an HIV medication could be causing it.

People who have HIV are more likely to get viral infections. Herpes zoster, herpes simplex, and Molluscum contagiosum can cause rashes or blisters.

Kaposiâs sarcoma causes lesions, patches, or nodules that are a different color from your skin. Sometimes, you can also get lesions on your internal organs. These may be life-threatening.

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