What Are Signs And Symptoms Of Hiv Infection And Aids In Men Women And Children
The time from HIV infection to the development of AIDS varies. Rarely, some individuals develop complications of HIV that define AIDS within one year, while others remain completely asymptomatic after as many as 20 years from the time of infection. However, in the absence of antiretroviral therapy, the time for progression from initial infection to AIDS is approximately eight to 10 years. The reason why people experience clinical progression of HIV at different rates remains an area of active research.
Within weeks of infection, many people will develop the varied symptoms of primary or acute infection, which typically has been described as a mononucleosis– or influenza-like illness but can range from minimal fever, aches, and pains to very severe symptoms. The most common symptoms of primary HIV infection are
- fever,
How Is Hiv Diagnosed
A doctor may suspect HIV if symptoms last and no other cause can be found.
If you have been exposed to HIV, your immune system will make antibodies to try to destroy the virus. Doctors use tests to find these HIV antibodies or antigens in urine, saliva, or blood.
If a test on urine or saliva shows that you are infected with HIV, you will probably have a blood test to confirm the results.
Most doctors use a blood test to diagnose HIV infection. If the test is positive , a test to detect HIV DNA or RNA will be done to be sure.
HIV antibodies may show up in the blood as early as 2 to 4 weeks after contact but can also take as long as 3 to 6 months to show up in the blood. If you think you have been exposed to HIV but you test negative for it:
- Get tested again. A repeat test can be done after a few weeks to be sure you are not infected.
- Meanwhile, take steps to prevent the spread of the virus, in case you do have it.
You can get HIV testing in most doctors’ offices, public health units, hospitals, and HIV care clinics.
Suspected Or Known Exposure To Hiv But No Symptoms
If you have not been tested for HIV, call your doctor if:
- You suspect that you have been exposed to HIV.
- You have engaged in high-risk behaviour and are concerned that you were exposed to HIV.
- Your sex partner engages in high-risk behaviour.
- Your sex partner may have been exposed to HIV.
- Your sex partner has HIV.
- You have any of the symptoms listed above.
Getting tested for HIV can be scary, but the condition can be managed with treatment. So it is important to get tested if you think you have been exposed.
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Testing Positive For Hiv
If you test positive, your doctor will complete a medical history and physical examination.
He or she may order several lab tests to check your overall health, including:
- A complete blood count , to identify the numbers and types of cells in your blood.
- A chemistry screen, to measure the blood levels of certain substances and to see how well your liver and kidneys are working.
Other tests may be done to check for current or past infections that may become worse because of HIV. You may be tested for:
How Do I Know If I Have Hiv
The only way to know for sure if you have HIV is to get tested. Testing is relatively simple. You can ask your health care provider for an HIV test. Many medical clinics, substance abuse programs, community health centers, and hospitals offer them too. You can also buy a home testing kit at a pharmacy or online.
To find an HIV testing location near you, use the HIV Services Locator.
HIV self-testing is also an option. Self-testing allows people to take an HIV test and find out their result in their own home or other private location. You can buy a self-test kit at a pharmacy or online. Some health departments or community-based organizations also provide self-test kits for free.
Read the U.S. Food and Drug Administrations fact sheet on the OraQuick In-Home HIV Test, the only FDA-approved in-home HIV test.
The coronavirus pandemic has made it more difficult for some people to access traditional places where HIV testing is provided. Self-testing allows people to get tested for HIV while still following stay-at-home orders and social distancing practices. Ask your local health department or HIV service organization if they offer self-testing kits.
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What Are Nucleoside And Nucleotide Analogue Reverse Transcriptase Inhibitors
NRTIs block an enzyme of the human immunodeficiency virus called reverse transcriptase that allows HIV to infect human cells, particularly CD4 cells or lymphocytes. Reverse transcriptase converts HIV genetic material, which is RNA, into human genetic material, which is DNA. The human-like DNA of HIV then becomes part of the infected person’s own cells, allowing the cell to produce RNA copies of the HIV that can then go on to attack other not yet infected cells. Thus, blocking reverse transcriptase prevents HIV from taking over human cells.
What are the usual dosing schedule and meal restrictions for NRTIs?
| ZDV |
|---|
- DRV/COBI/FTC/TAF as Symtuza
- DOR/3TC/TDF as Delstrigo
- DTG/RPV as , which is only approved for those stably suppressed on an alternative regimen with no history of drug resistance
Where Did Hiv Come From
The earliest known case of infection with HIV-1 in a human was detected in a blood sample collected in 1959 from a man in Kinshasa, Democratic Republic of the Congo. Genetic analysis of this blood sample suggested that HIV-1 may have stemmed from a single virus in the late 1940s or early 1950s.
We know that the virus has existed in the United States since at least the mid- to late 1970s. From 19791981 rare types of pneumonia, cancer, and other illnesses were being reported by doctors in Los Angeles and New York among a number of male patients who had sex with other men. These were conditions not usually found in people with healthy immune systems.
In 1982 public health officials began to use the term “acquired immunodeficiency syndrome,” or AIDS, to describe the occurrences of opportunistic infections, Kaposi’s sarcoma , and Pneumocystis jirovecii pneumonia in previously healthy people. Formal tracking of AIDS cases began that year in the United States.
In 1983, scientists discovered the virus that causes AIDS. The virus was at first named HTLV-III/LAV by an international scientific committee. This name was later changed to HIV .
For more information on this discovery, visit the NIH National Institute of Allergy and Infectious Diseases press release. For information on the theory that HIV originated in polio vaccines, visit the CDC Vaccine Safety site.
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Hiv Transmission In Australia
In Australia, HIV is commonly transmitted through:
- Unprotected anal or vaginal sex .
- Sharing any needles, syringes, or other injecting equipment.
- From mother to child during pregnancy, childbirth, or breastfeeding This can occur when the mother doesnt know she is HIV-positive, or is not on effective treatment.
- Tattooing or other procedures that involve unsterile or reused equipment.
- Needle stick injuries.
HIV is not transmitted by:
- kissing, hugging, massaging, mutual masturbation and other body contact
- social interaction
- sharing food, dishes, utensils, drinking glasses
- air, breath, or being coughed or sneezed on
- mosquito, insect or animal bites
- use of communal facilities .
It is perfectly safe to consume food and drinks prepared by someone who is HIV-positive even if theyre not receiving treatment.
People with HIV who are on treatment and achieve and maintain an undetectable HIV viral load cannot transmit HIV sexually.
Talk With Your Hiv Health Care Provider
Talk with your health care provider about the benefits of HIV treatment and which HIV medication is right for you. Discuss how frequently you should get your viral load tested to make sure it remains undetectable.
If your lab results show that the virus is detectable or if you are having trouble taking every dose of your medication, you can still protect your HIV-negative partner by using other methods of preventing sexual transmission of HIV such as condoms, safer sex practices, and/or pre-exposure prophylaxis for an HIV-negative partner until your viral load is undetectable again.
Taking HIV medicine to maintain an undetectable viral load does not protect you or your partner from getting other sexually transmitted diseases , so talk to your provider about ways to prevent other STDs.
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History Of Hiv And Aids Overview
KEY POINTS:
The history of the HIV and AIDS epidemic began in illness, fear and death as the world faced a new and unknown virus. However, scientific advances, such as the development of antiretroviral drugs, have enabled people with access to treatment to live long and healthy lives with HIV.
Here, we go through the key historical moments that have defined the HIV epidemic over the past 30 years.
How Does Hiv Affect The Body
The human immune system involves many types of cells which guard against germs responsible for most diseases. The immune system’s most important guard cells are B-cells and T-cells, which are special white blood cells. B-cells and T-cells cooperate to fight any germ that attacks the human body.
B-cells produce particular proteins, called antibodies, that try to neutralize the invading germ. After a person recovers from an infection, these antibodies continue to circulate in the bloodstream, acting as part of the immune system’s “memory.” Immune system memory explains why a person rarely suffers a second attack from an infectious disease such as measles. If the same germ is encountered again, the antibodies will recognize and neutralize it. T-cells attack the germ directly and try to kill it.
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Living With Hiv: What To Expect And Tips For Coping
More than 1.2 million people in the United States are living with HIV. Its different for everybody, but with treatment, many can expect to live a long, productive life.
The most important thing is to start antiretroviral treatment as soon as possible. By taking medications exactly as prescribed, people living with HIV can keep their viral load low and their immune system strong.
Its also important to follow up with a healthcare provider regularly.
Other ways people living with HIV can improve their health include:
- Make their health their top priority. Steps to help people living with HIV feel their best include:
- fueling their body with a well-balanced diet
- exercising regularly
- avoiding tobacco and other drugs
- reporting any new symptoms to their healthcare provider right away
Canadian Flight Attendant Theory
A Canadian airline steward named Gaëtan Dugas was referred to as “Case 057” and later “Patient O” with the alphabet letter “O” standing for “outside Southern California”, in an early AIDS study by Dr. William Darrow of the Centers for Disease Control. Because of this, many people had considered Dugas to be responsible for taking HIV to North America. However, HIV reached New York City around 1971 while Dugas did not start work at Air Canada until 1974. In Randy Shilts‘ 1987 book And the Band Played On , Dugas is referred to as AIDS’s Patient Zero instead of “Patient O”, but neither the book nor the movie states that he had been the first to bring the virus to North America. He was incorrectly called “Patient Zero” because at least 40 of the 248 people known to be infected by HIV in 1983 had had sex with him, or with a person who had sexual intercourse with Dugas.
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What Is In The Future For Preventing Hiv Transmission
Early advances in preventing HIV transmission resulted from educational programs describing how transmission occurs and providing barrier protection for those exposed to genital secretions and new needles or bleach to those exposed to blood by sharing needles. Despite these efforts, new infection in both the developed and developing worlds has continued at high rates.
Historically, the greatest success in preventing viral transmission has resulted from the development of preventative vaccines. Unfortunately, decades of research to develop an HIV vaccine has led to little hope for success. In 2007, a major setback in this area occurred when the STEP study investigating a promising vaccine candidate was prematurely stopped due to the lack of evidence that it produced any protection from HIV infection. In contrast, a glimmer of hope did emerge with the report in 2009 of the results of the RV 144 Thai HIV vaccine trial, which demonstrated borderline effectiveness in the more than 16,000 recipients. While this vaccine demonstrated only limited evidence of protection, research is under way to further explore what can be learned for future vaccine development from this modest success.
Treatment Options For Hiv
Treatment should begin as soon as possible after a diagnosis of HIV, regardless of viral load.
The main treatment for HIV is antiretroviral therapy, a combination of daily medications that stop the virus from reproducing. This helps protect CD4 cells, keeping the immune system strong enough to take measures against disease.
Antiretroviral therapy helps keep HIV from progressing to AIDS. It also helps reduce the risk of transmitting HIV to others.
When treatment is effective, the viral load will be undetectable. The person still has HIV, but the virus is not visible in test results.
However, the virus is still in the body. And if that person stops taking antiretroviral therapy, the viral load will increase again, and the HIV can again start attacking CD4 cells.
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Hiv And Aids Treatment
More than 25 antiretroviral therapy drugs are approved to treat the virus. Your doctor will prescribe a mix of these medications.
The drugs will help stop HIV from making copies of itself. That will keep you healthy and lower your risk of spreading it.
Thereâs no cure for HIV or AIDS. ARTâs goal is to lower your viral load and keep your immune system healthy. The idea is to lower the viral load to âundetectableâ and keep it that way, by taking your medicine every day as prescribed.
Taking Hiv Medication To Stay Healthy And Prevent Transmission
If you have HIV, it is important to start treatment with HIV medication as soon as possible after your diagnosis.
If taken every day, exactly as prescribed, HIV medication can reduce the amount of HIV in your blood to a very low level. This is called viral suppression. It is called viral suppression because HIV medication prevents the virus from growing in your body and keeps the virus very low or suppressed. Viral suppression helps keep you healthy and prevents illness.
If your viral load is so low that it doesnt show up in a standard lab test, this is called having an undetectable viral load. People living with HIV can get and keep an undetectable viral load by taking HIV medication every day, exactly as prescribed. Almost everyone who takes HIV medication daily as prescribed can achieve an undetectable viral load, usually within 6 months after starting treatment.
There are important health benefits to getting the viral load as low as possible. People living with HIV who know their status, take HIV medication daily as prescribed, and get and keep an undetectable viral load can live long, healthy lives.
There is also a major prevention benefit. People living with HIV who take HIV medication daily as prescribed and get and keep an undetectable viral load have effectively no risk of sexually transmitting HIV to their HIV-negative partners.
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Why Is Haiti Significant
In the 1960s, the ‘B’ subtype of HIV-1 had made its way to Haiti. At this time, many Haitian professionals who were working in the colonial Democratic Republic of Congo during the 1960s returned to Haiti.13 Initially, they were blamed for being responsible for the HIV epidemic, and suffered severe racism, stigma and discrimination as a result.
HIV-1 subtype M is now the most geographically spread subtype of HIV internationally. By 2014, this subtype had caused 75 million infections.14
If You Already Have Hiv
If you are infected with HIV, you can greatly lower the risk of spreading the infection to your sex partner by starting treatment when your immune system is still healthy.
Experts recommend starting treatment as soon as you know you are infected.footnote 21
Studies have shown that early treatment greatly lowers the risk of spreading HIV to an uninfected partner.footnote 22, footnote 23
Your partner may also be able to take medicine to prevent getting infected.footnote 17 This is called pre-exposure prophylaxis .
Steps to avoid spreading HIV
If you are infected with HIV, you can greatly lower the risk of spreading the infection to your sex partner by starting treatment when your immune system is still healthy.
- Take antiretroviral medicines. Getting treated for HIV can help prevent the spread of HIV to people who are not infected.
- Tell your sex partner or partners about your behaviour and whether you are HIV-positive.
- Follow safer sex practices, such as using condoms.
- Do not donate blood, plasma, semen, body organs, or body tissues.
- Do not share personal items, such as toothbrushes, razors, or sex toys, that may be contaminated with blood, semen, or vaginal fluids.
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